This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The translation of messenger RNA, or mRNA, is fundamental to eukaryotic life as we know it. So when mRNA is mistranslated, abnormalities like cancer can arise. That has cancer researchers targeting proteins called eukaryotic initiation factors, or eIFs. eIFs regulate the early stages of translation known as initiation. Research shows that in mammals, eIFs themselves are regulated by a protein complex known as mTORC1. mTORC1 helps stimulate protein production, which in cancer translates to tumor proliferation and survival. Together, eIFs and mTORC1 recruit an array of signaling pathways that serve as the machinery for cancer growth. Researchers are currently developing several ways of stopping that machinery in the fight against cancer, such as phosphorylating the protein eIF2α to induce cancer cell death or inhibiting the protein eIF4A using known small-molecule compounds. Over the past two decades, researchers have made much progress in identifying drugs that target eIFs..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

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