By the end of this section, you will be able to:Understand how the cell cycle is controlled by mechanisms both internal and external to the cellExplain how the three internal control checkpoints occur at the end of G1, at the G2/M transition, and during metaphaseDescribe the molecules that control the cell cycle through positive and negative regulation

Biology is designed for multi-semester biology courses for science majors. It is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand. To meet the needs of today’s instructors and students, some content has been strategically condensed while maintaining the overall scope and coverage of traditional texts for this course. Instructors can customize the book, adapting it to the approach that works best in their classroom. Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand—and apply—key concepts.

By the end of this section, you will be able to:Understand how the cell cycle is controlled by mechanisms both internal and external to the cellExplain how the three internal control checkpoints occur at the end of G1, at the G2/M transition, and during metaphaseDescribe the molecules that control the cell cycle through positive and negative regulation

By the end of this section, you will be able to:Understand how the cell cycle is controlled by mechanisms both internal and external to the cellExplain how the three internal control checkpoints occur at the end of G1, at the G2/M transition, and during metaphaseDescribe the molecules that control the cell cycle through positive and negative regulation

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"p53 is widely considered the most frequently mutated gene in human disease, including in cancer. Normally, p53 acts as a checkpoint for recognizing DNA damage and actually suppresses tumor formation. Alterations to p53 compromise this function and can make way for life-threatening tumor growth. A new study examined how abnormal p53 might create conditions favorable for one of the most aggressive forms of ovarian carcinoma. The authors of the study began by knocking the p53 gene out of ovarian carcinoma cells and monitoring the effects. Next-generation sequencing of the p53-less cells revealed significantly elevated expression of fibronectin, a structural protein linked to various carcinomas. Loss of p53 function also appeared to boost the cancer cells’ ability to migrate and spread. Data on actual patients with ovarian cancer confirmed the pattern observed in the lab..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Immunotherapy is one of the most powerful weapons for fighting cancer. This approach re-activates the anti-tumor activity of compromised immune cells, but one glaring weakness is that it can over-activate the immune system, leading to adverse events that can range from mild headache to anaphylaxis. That has some researchers turning to the gut for solutions. The intestinal microbiome is a complex ecosystem that regulates our physiology and psychology, both in health and in diseases such as cancer. Growing evidence suggests that certain microbes could be harnessed to boost anti-cancer immunotherapies. These microbes could secrete molecules that promote the spread of immune cells that target tumors or enhance immune cells’ ability to recognize cancer. Bolstered by recent advancements in sequencing techniques, microbiome research could be the perfect complement to cancer immunotherapy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.