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Biomolecular Kinetics and Cellular Dynamics (BE.420J)
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CC BY-NC-SA
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This subject deals primarily with kinetic and equilibrium mathematical models of biomolecular interactions, as well as the application of these quantitative analyses to biological problems across a wide range of levels of organization, from individual molecular interactions to populations of cells.

Subject:
Applied Science
Biology
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Tidor, Bruce
Wittrup, Karl
Date Added:
09/01/2004
Intrinsically disordered proteins play diverse roles in cell signaling
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Molecular signaling pathways are crucial for cellular function and communication. In order to work properly, the pathways must be sensitive, adaptable, and tunable to specific stimuli and situations. These essential qualities are made possible by intrinsically disordered proteins (IDPs). IDPs can’t fold into stable, defined structures on their own, but many IDPs can gain at least some structure when they bind with specific partners. These and other interactions change the IDPs’ conformations to enable specific and reversible binding, giving the signaling pathways the sensitivity and flexibility they need to function correctly. Algorithms and other computational tools can help identify IDPs and predict their functions. So far, such tools have revealed that IDPs are pervasive in all kingdoms of life. In addition, they’ve shown that IDPs help relay signals from diverse stimuli, such as ions, lipids, proteins, chemicals, and environmental cues in every category of cell signaling pathway and at every step..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022
Kidney Stone Crystallization
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Educational Use
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Students learn how crystallization and inhibition occur by examining calcium oxalate crystals with and without inhibitors that are capable of altering crystallization. Kidney stones are composed of calcium oxalate crystals, and engineers and doctors experiment with these crystals to determine how growth is affected when a potential drug is introduced. Students play the role of engineers by trying to determine which inhibitor would be the best for blocking crystallization.

Subject:
Applied Science
Chemistry
Engineering
Physical Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Andrea Lee
Megan Ketchum
Date Added:
10/14/2015
Language Acquisition I
Conditional Remix & Share Permitted
CC BY-NC-SA
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This course focuses on the process by which native speakers of a language acquire the ability to speak and understand that language. It covers some of the major results in the study of first-language acquisition, concentrating on morpho-syntax, semantics, and pragmatics. The findings primarily come from English, but cross-linguistic differences in the phenomena of interest and corresponding differences in acquisition patterns are considered where appropriate. Of interest throughout is how these developmental data inform linguistic theory and/or learnability theory.

Subject:
Arts and Humanities
Linguistics
Social Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Aravind, Athulya
Date Added:
09/01/2020
Linguistic Theory and the Japanese Language
Conditional Remix & Share Permitted
CC BY-NC-SA
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This course is a detailed examination of the grammar of Japanese and its structure which is significantly different from English, with special emphasis on problems of interest in the study of linguistic universals. Data from a broad group of languages is studied for comparison with Japanese. This course assumes familiarity with linguistic theory.

Subject:
Arts and Humanities
Languages
Linguistics
Social Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Miyagawa, Shigeru
Date Added:
09/01/2004
Rock Candy Your Body
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Educational Use
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Students see and learn how crystallization and inhibition occur by making sugar crystals with and without additives in a supersaturation solution, testing to see how the additives may alter crystallization, such as by improving crystal growth by more or larger crystals. After three days, students analyze the differences between the control crystals and those grown with additives, researching and attempting to deduce why certain additives blocked crystallization, showed no change or improved growth. Students relate what they learn from the rock candy experimentation to engineering drug researchers who design medicines for targeted purposes in the human body. Conduct the first half of this activity one day before presenting the associated lesson, Body Full of Crystals. Then conduct the second half of the activity.

Subject:
Applied Science
Chemistry
Engineering
Physical Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Andrea Lee
Megan Ketchum
Date Added:
10/14/2015