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Plakins and their role in ovarian cancer progression, chemoresistance, and recurrence
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Plakin proteins are a family of large cytoskeletal proteins whose primary role is maintaining cytoskeletal integrity, but they are also essential in maintaining the network between cytoskeleton, plasma membrane, and intracellular organelles. Many cancers show increased plakin expression in tumors compared to normal tissue. In fact, in colon and breast cancer, plakins are directly involved in metastatic processes, but they are chronically under-studied in cancer, despite playing such an important role. A recent review explored the roles they play in disease-states, particularly cancers, with an emphasis on ovarian cancer. Ovarian cancer patients are typically not diagnosed until late-stage disease, but plakin proteins show promise as an early-stage biomarker. The current body of research shows crucial plakin expression changes in ovarian cancer progression and recurrence. For example, changes in plakin expression may drive the transition from benign ovarian tumors to carcinomas..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/13/2021