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Disturbances to biological clock could make osteoarthritis worse
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Our biological clock regulates everything from our body temperature to our eating habits. So much so that anything that throws it off beat could allow diseases to set in, including osteoarthritis. Muscle, bone, cartilage, and the tissue in between are reported to have regular rhythms that maintain joint health, and studies suggest that disturbances in the genes that regulate these rhythms could make symptoms of osteoarthritis worse. These disturbances affect the cells responsible for creating cartilage, increasing their breakdown while slowing their buildup. They lead to abnormal remodeling of bone tissue. They cause muscle fibers to age faster and become weaker. And they lead to inflammation in surrounding tissue, which aggravates joint pain and damage. Research that examines the relationship between rhythmic disturbances and osteoarthritis could lead to new ways of understanding joint degeneration and could inspire the development of new drugs that target the mechanisms underlying osteoarthritis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
03/01/2023
Psoriasis (Spanish)
Read the Fine Print
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This patient education program explains psoriasis, the causes, symptoms, diagnosis, and the benefits and risks of different treatment options. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Lecture
Provider:
National Library of Medicine
Provider Set:
H.E.A.L.
Date Added:
11/17/2003
Repair of medial meniscus root tear could prevent progression to arthritis and subsequent knee arthroplasty
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The root of the medial meniscus is a vital component that provides stability and cushions axial loads to protect the knee. For that reason, meniscal root tears can be especially debilitating; studies have shown that tearing the posterior root of the medial meniscus is functionally and biomechanically comparable to a complete meniscectomy. Historically, such tears were treated without surgery or with partial removal of the meniscus. Now, clinicians are shifting toward preserving the biomechanical function of the medial meniscus through root repair. While good outcomes have been reported for this surgical treatment option, relatively few studies have compared root repair with other treatment methods. Authors of a recent study compared the long-term outcomes of nonoperative management or partial meniscectomy with those of root repair by the transtibial pull-through technique..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
02/14/2020
Structural abnormalities in knee point to high risk of cartilage degeneration
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Knee problems such as instability of the kneecap and arthritis can be telltale signs that it’s time for surgery. But they’re not the only ones. A new study suggests that focal lesions of the cartilage that cushions the kneecap, or patella, and of the trochlea, the groove where the patella rests, are just as important and can have similar causes. Understanding how these lesions are related to knee alignment and morphology could help clinicians develop more tailored and durable treatments. Researchers reached that conclusion after comparing the knee anatomy of 135 patients with focal patellofemoral cartilage lesions, but no arthritis, to that of 100 patients with normal cartilage. Using M-R-I, they assessed features including patellar morphology, trochlear morphology, patellar malalignment, and the quadriceps vector. Patients with patellofemoral lesions showed greater trochlear dysplasia and patellar malalignment than those in the control group..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/27/2019