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B cell differentiation
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Mature B cells that undergo stimulation by an antigen undergo class switching, ...

Mature B cells that undergo stimulation by an antigen undergo class switching, and differentiate into either plasma or memory cells. In the paracortex region of the lymph node binding to MHC II in the presence of IL-4 produced by the CD4+ T cells (TH2 type) causes the B cells to differentiate; most will become plasma cells, however a small number will become memory cells. Follicular dendritic cells present in the germinal centers of peripheral lymphoid organs can absorb intact antigen onto their surface to present to B cells to stimulate differentiation.

Subject:
Life Science
Material Type:
Images and Illustrations
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Provider:
WikiVet
Provider Set:
Blood
Cloning an Army of T Cells for Immune Defense
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Read the Fine Print
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View the animation to see how one type of immune cell-the helper ...

View the animation to see how one type of immune cell-the helper T cell-interprets a message presented at the surface of the cell membrane. The message is an antigen, a protein fragment taken from an invading microbe. A series of events unfolds that results in the production of many clones of the helper T cell. These identical T cells can serve as a brigade forming an essential communication network to activate B cells, which make antibodies that will specifically attack the activating antigen.

Subject:
Chemistry
Material Type:
Video Lectures
Provider:
Howard Hughes Medical Institute
Major Histocompatability Complexes
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T-cells rely on Major Histocompatability Complexes (MHC), which are molecules manufactured within ...

T-cells rely on Major Histocompatability Complexes (MHC), which are molecules manufactured within cells for the purpose of presenting antigen fragments so that they can be detected by the immune system. MHC has evolved to form two classes for antigen presentation: MHC I presents digested fragments from antigen in cellular cytoplasm, and MHC II presents digested fragments from antigen in the tissue fluid (extracellular). MHC I tends to bind slightly smaller peptides (~9 amino acids) than MHC II (~15 amino acids).

Subject:
Life Science
Material Type:
Images and Illustrations
Readings
Provider:
WikiVet
Provider Set:
Blood
Natural Killer cells
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NK cells can be classified as lymphocytes because they are capable of ...

NK cells can be classified as lymphocytes because they are capable of recognising antigen, however they are more often associated with the innate immune response. They target cells by monitoring MHC production, which is expressed by healthy cells to present antigen to T-cells. Low MHC levels can be used as a marker for a cell whose machinery is compromised by a replicating virus. When MHC levels drop, it acts as a danger signal to the NK cells, which then release enzymes to kill the infected cells.

Subject:
Life Science
Material Type:
Images and Illustrations
Readings
Provider:
WikiVet
Provider Set:
Blood