This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study in rhesus monkeys clarifies one aspect of how the new drug cebranopadol relieves pain and finds that this effective analgesic has milder side effects than fentanyl and morphine. Pure mu opioid receptor agonists like fentanyl and morphine are the most widely used analgesic drugs in medical settings. However, their severe side effects and high abuse potential have prompted the need for alternatives. Treatment with drugs that simultaneously target nociceptin receptors and mu receptors has been shown to limit mu receptor-related side effects. Cebranopadol, an effective pain reliever in rodents and humans, targets nociceptin receptors and various opioid receptors. But whether the mu opioid receptor subtype is the most important for cebranopadol analgesia is unknown, and the associated side effects haven’t been investigated in nonhuman primate models. To better evaluate cebranopadol as an analgesic alternative to pure mu agonists, researchers compared it with fentanyl and morphine..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"When your cat is sick or painful, you take him or her to the veterinarian But pain behaviors are subtle and unique in cats - pain assessment can be difficult and they may not receive proper analgesic treatment Pain assessment tools have been created, but they can be time-consuming to use and can be affected by the cat’s demeanor Now, researchers at the Université de Montréal have developed the Feline Grimace Scale Similar to grimace scales in other species, the tool is a simple method of pain assessment using changes in facial expressions Using video recordings of 70 cats, the researchers compared the images of painful and non-painful cats using rigorous scientific methods They found that the position of the eyes, ears, whiskers, muzzle and head changes under painful conditions These changes will return to their normal position after the administration of pain killers Tests showed that the tool is accurate, valid and reliable, and a cut-off score for rescue analgesia was determined The Fel.."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Live donation of a kidney transplant carries various risks One concern is opioid exposure The use of narcotic pain medications in conjunction with general anesthesia can delay a donor’s return to normal daily function....."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.