This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"A team of researchers based at West Virginia University has devised an innovative way to potentially monitor enzyme activity in vivo using electron paramagnetic resonance imaging. The method could provide new insights into the molecular underpinnings of many types of disease. The team specifically focused on tracking enzymatic dephosphorylation. Abnormalities in dephosphorylation have been linked to disorders ranging from cancer to Alzheimer disease. Monitoring such malfunction in vivo can provide crucial details into disease state and progression, but direct measurement of enzyme activity within a living organism remains extremely challenging. Many imaging approaches that might be used for this purpose are hampered by concerns such as low sensitivity and penetration depth. Such limitations prompted the researchers to turn to EPRI – a method with high intrinsic sensitivity and specificity..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Craniopharyngiomas are among the most common calcified tumors in the central nervous system. Although calcification is known to complicate tumor removal, especially in the delicate central nervous system, the underlying mechanism is poorly understood. A recent study examined the calcification of adamantinomatous craniopharyngiomas. Using cultured primary cells, the researchers induced calcification with the protein Bmp2. Calcified cells had elevated expression of the histone deacetylase HDAC3. Paradoxically, however, inhibiting HDAC3 activity increased calcification and differentiation into osteoblasts. Researchers discovered that this disconnect between HDAC3 expression and its activity came down to its cellular location. Bmp2, it turned out, was blocking HDAC3 from relocating to the nucleus. Bmp2 blocked relocation indirectly by increasing the expression of the microRNA miR-181b. miR-181b decreased the expression of the protein CBX4, which normally stabilizes the nuclear localization of HDAC3..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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