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MUCO-DIS: A new AFM-based nanoscale dissolution technique
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Mucoadhesion is a powerful mode of drug delivery. Prolonged exposure to mucosal tissue allows for drug release over an extended period of time, improving both compliance with drug treatment and convenience of use among patients. Unfortunately, there is no standard method for evaluating the performance of different mucoadesive drug formulations. Now, there’s MUCO-DIS, developed by University of Huddersfield. MUCO-DIS is an AFM- and microfluidics-based system that simultaneously measures four core functional properties of mucoadhesive formulations at the nanoscale: mucoadhesion force, 3D surface topography, polymer dissolution, and drug release characteristics. Researchers at University of Huddersfield used this newly developed MUCO-DIS to evaluate the performance of metformin mucoadhesive formulation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/01/2020
Micro/Nano Engineering Laboratory
Conditional Remix & Share Permitted
CC BY-NC-SA
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This course encourages creative thinking through hands-on experience via building, observing and manipulating micro-and nano-scale structures. Students learn about underlying science and engineering principles and possible applications.

Subject:
Applied Science
Engineering
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Comeau, Benita
Herrick, Daniel
Karnik, Rohit
Kim, Jeehwan
Kim, Sang-Gook
Kolle, Mathias
Date Added:
02/01/2016
Nanomechanics of Materials and Biomaterials
Conditional Remix & Share Permitted
CC BY-NC-SA
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This course focuses on the latest scientific developments and discoveries in the field of nanomechanics, the study of forces and motion on extremely tiny (10 m) areas of synthetic and biological materials and structures. At this level, mechanical properties are intimately related to chemistry, physics, and quantum mechanics. Most lectures will consist of a theoretical component that will then be compared to recent experimental data (case studies) in the literature. The course begins with a series of introductory lectures that describes the normal and lateral forces acting at the atomic scale. The following discussions include experimental techniques in high resolution force spectroscopy, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of single macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors.

Subject:
Applied Science
Biology
Chemistry
Engineering
Life Science
Physical Science
Physics
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Ortiz, Christine
Date Added:
02/01/2007