This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Birds can carry and transmit viruses to humans and other animals. Thus, understanding the viral community hosted by birds could help us predict future outbreaks of human disease. A recent metagenomics study took a broad look at the viruses found in the gut of wild and captive birds. The dataset included samples from over 3,000 birds that represented over 87 species and 10 different phylogenetic orders and the researchers characterized genomes from numerous viral families including astroviruses, coronaviruses, parvoviruses, and adenoviruses. Examining trends, they found that wild birds had higher viral diversity than captive birds. There was also evidence of potential cross-species transmission between wild birds and domestic poultry. Further analysis of the viral genomic sequences revealed differences in virus distribution patterns between wild and captive birds. Different phylogenetic orders of birds and geographic sites also had distinct distribution patterns..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Researchers are combining tumor-killing viruses with immune-boosting drugs to mark otherwise stealthy tumors for death In their recent study, the researchers grafted human melanoma tumors onto the left and right flanks of mice Right-side tumors were injected with ONCOS-102, viruses genetically modified to eradicate melanoma cells Left-side tumors were left untreated The team then injected mice with pembrolizumab, a checkpoint inhibitor Checkpoint inhibitors block cloaking proteins on tumor or T cells that normally let them slip past immune cells These powerful drugs turn “cold” tumors “hot” on immune cells’ radar Shrunken left-side tumors proved that this 1-2 combination could cripple tumors at a distance— an effect amplified by delivering ONCOS-102 and pembrolizumab at the same time Now, in order to prove the efficacy of ONCOS-102 combined with pembrolizumab in humans, a Phase I clinical study is ongoing (NCT03003676) Researchers are exploring how to make this killer combi.."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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