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  • The Human Genome
Bioinformatics, Virtual Labs, and the Human Genome Project
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Bioinformatics, Virtual Labs, and the Human Genome Project
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This session introduces bioinformatics using a case study of pathogenic bacterial identification ...

This session introduces bioinformatics using a case study of pathogenic bacterial identification via a Howard Hughes Medical Institute's virtual lab and NCBI web database searches. Another goal is to get the students thinking, writing and talking about the impact of the human genome project. Our students do the exercise independently coming together in the laboratory to present and discuss their findings--this feature makes the exercise feasible for large or small classes with limited laboratory computer resources. The sub-theme of this session is the use of virtual laboratories (vlabs) re-enforcing scientific concepts and methods to supplement lectures, tutorials or "wet" labs.

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Subject:
Biology
Material Type:
Activities and Labs
Case Study
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Anne L. Cordon
Donna Messersmith
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Genomics and Its Impact on Science and Society: The Human Genome Project and Beyond (2008)
Conditions of Use:
Read the Fine Print
Genomics and Its Impact on Science and Society: The Human Genome Project and Beyond (2008)
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This site gives a detailed overview of the science of genetics, including ...

This site gives a detailed overview of the science of genetics, including the Human Genome Project. An introduction helps visitors understand genomes, DNA, genes, chromosomes, and more. Other resources include online audio and video files about genetics and the Human Genome Project, images of genomes, current research news, a glossary, frequently asked questions, and a student page.

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Subject:
Genetics
Material Type:
Readings
Provider:
U.S. Department of Energy
Provider Set:
Oak Ridge National Laboratory
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The Science Scoop: The Human Genome Project
Conditions of Use:
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The Science Scoop: The Human Genome Project
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This fun Web site is part of OLogy, where kids can collect ...

This fun Web site is part of OLogy, where kids can collect virtual trading cards and create projects with them. Here, they learn about the human genome project by clicking through an online slide show, hosted by kids, that answers these questions: What's a genome, anyway?What is the human genome project? What does it mean to me?

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Subject:
Biology
Genetics
Material Type:
Readings
Provider:
American Museum of Natural History
Provider Set:
American Museum of Natural History
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Language & Life Sciences: Mapping the Human Genome
Conditions of Use:
No Strings Attached
Language & Life Sciences: Mapping the Human Genome
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Rather than focus on the scientific details of this discovery, this chapter ...

Rather than focus on the scientific details of this discovery, this chapter gives an overview of the important concepts related to DNA's initial discovery and later research conducted in this field. Teachers can use the lesson plans and materials to help students understand these fundamental concepts and gain a command of the vocabulary necessary to discuss them. Given the amazing advances in biological research and the new knowledge that has become available to human beings about their own biological makeup, it is important for students to know basic concepts related to DNA research and the human genome project. This following lesson provides a basic introduction to this topic in an interactive fashion.

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Subject:
Language Education (ESL)
Biology
Material Type:
Lesson Plans
Teaching and Learning Strategies
Provider:
U.S. Department of State, Bureau of Educational and Cultural Affairs
Provider Set:
U.S. Department of State Bureau of Educational and Cultural Affairs
Author:
Donna M. Brinton, Christine Holten, Jodi L. Nooyen
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Bioinformatics
Conditions of Use:
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Bioinformatics
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This exercise contains two interrelated modules that introduce students to modern biological ...

This exercise contains two interrelated modules that introduce students to modern biological techniques in the area of Bioinformatics, which is the application of computer technology to the management of biological information. The need for Bioinformatics has arisen from the recent explosion of publicly available genomic information, such as that resulting from the Human Genome Project.

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Subject:
Biology
Material Type:
Activities and Labs
Data
Instructional Material
Provider:
Science Education Resource Center (SERC) at Carleton College
Provider Set:
Pedagogy in Action
Teaching With Data
Author:
By Monica Bruckner, Montana State University; Based on the Bioinformatics Exercise by Seth Bordenstein.
Monica Bruckner
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The Science Scoop: The Human Genome Project
Conditions of Use:
Read the Fine Print
The Science Scoop: The Human Genome Project
Rating

This fun Web site is part of OLogy, where kids can collect ...

This fun Web site is part of OLogy, where kids can collect virtual trading cards and create projects with them. Here, they learn about the human genome project by clicking through an online slide show, hosted by kids, that answers these questions: What's a genome, anyway? What is the human genome project? What does it mean to me?

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Subject:
Life Science
Genetics
Material Type:
Reference
Provider:
American Museum of Natural History
Provider Set:
American Museum of Natural History
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High School Human Genome Project
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High School Human Genome Project
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The High School Human Genome Program allows high school students to sequence ...

The High School Human Genome Program allows high school students to sequence DNA in their classrooms and to contribute their data to the Human Genome Project. The program was developed jointly by scientists from the University of Washington's Department of Molecular Biotechnology and high school teachers from the Puget Sound region. The goals of the program are to promote a better understanding of DNA research among students by enabling them, under the guidance of their teachers, to sequence portions of the human genome; to stimulate students interest in the ethical, legal and social implications of genome research; and to interest students in careers in science.

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Genetics
Conditions of Use:
Read the Fine Print
Genetics
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Genetics is the branch of biology that studies the means by which ...

Genetics is the branch of biology that studies the means by which traits are passed on from one generation to the next and the causes of similarities and differences between related individuals. In this course, the student will take a close look at chromosomes, DNA, and genes. The student will learn how hereditary information is transferred, how it can change, how it can lead to human disease and be tested to indicate disease, and much more. Upon successful completion of this course, students will be able to: give a brief synopsis of the history of genetics by explaining the fundamental genetic concepts covered in this course as they were discovered through time; identify the links between Mendel's discoveries (often represented by Punnett squares) with mitosis and meiosis, dominance, penetrance, and linkage; recognize the role of simple probability in genetic inheritance; apply advanced genetic concepts, including genetic mapping and transposons, to practical applications, including pedigree analysis and corn kernel color; identify the cause behind several genetic diseases currently prevalent in society (such as color blindness and hemophilia) and recognize the importance of genetic illness throughout history; compare and contrast advanced concepts of chromosomal, bacterial, human, and population genetics; recognize the similarities and differences between nuclear, chloroplast, and mitochondrial DNA; describe the fundamentals of population genetics, calculate gene frequencies in a give scenario, predict future gene frequencies over future generations, and define the role of evolution in gene frequency shift over time; recall, analyze, synthesize, and build on the foundational material to then learn the cutting-edge technological advances in genetics, including genomics, population and evolutionary genetics, and QTL mapping. (Biology 305)

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Subject:
Biology
Genetics
Material Type:
Activities and Labs
Assessments
Audio Lectures
Full Course
Homework and Assignments
Lecture Notes
Readings
Simulations
Syllabi
Video Lectures
Provider:
The Saylor Foundation
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National Human Genome Research Institute
Conditions of Use:
No Strings Attached
National Human Genome Research Institute
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The National Human Genome Research Institute began as the National Center for ...

The National Human Genome Research Institute began as the National Center for Human Genome Research (NCHGR), which was established in 1989 to carry out the role of the National Institutes of Health (NIH) in the International Human Genome Project (HGP). The HGP was developed in collaboration with the United States Department of Energy (DOE) and begun in 1990 to map the human genome.

Now, with the human genome sequence complete since April 2003, scientists around the world have access to a database that greatly facilitates and accelerates the pace of biomedical research.

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DNA Sequencing Used to Illustrate Mutations and Evolution
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DNA Sequencing Used to Illustrate Mutations and Evolution
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This workshop, which is half wet lab and half Internet lab, uses ...

This workshop, which is half wet lab and half Internet lab, uses DNA sequences to examine the relatedness of different species. DNA from several insect and/or fish species are compared. This chapter includes instructions for extracting DNA from gels and making PCR products. We prepare PCR products to send to a computerized automated sequencing facility. (No radioisotopes are used in this sequencing!) We recover sequence from the facility over the Web as four-color graphics on a computer screen and as text. We make pair-wise DNA sequence comparisons between species with BLAST2 and multi-species comparisons with MultAlin. We see substitutions, insertions, and deletions. Then we make a distance-based evolutionary tree with GeneBee.

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Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Kathleen A. Nolan
Russell LeMon
Theodore Gurney
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Introduction to Bioinformatics (Slides)
Conditions of Use:
Remix and Share
Introduction to Bioinformatics (Slides)
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This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides ...

This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides and DNA. The presentation then explains what bioinformatics is, lists some examples, and demonstrates some tools. It demonstrates tools which compare parts of human and chimp genes, and illustrate drug resistance analysis and HIV subtype analysis. It then discusses some ethical and clinical aspects to bioinformatics.

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Material Type:
Textbooks
Provider:
Global Health Informatics Partnership (GHIP)
OER Africa
Author:
Singh, Yashik
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Genetic Origins
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Read the Fine Print
Genetic Origins
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The goal of the Genetic Origins Program is to allow students to ...

The goal of the Genetic Origins Program is to allow students to use their own DNA variations (polymorphisms) as a means to explore our shared genetic heritage and its implications for human health and society. Genetic Origins focuses on two types of DNA variations: an Alu insertion polymorphism on chromosome 16 (PV92) and single nucleotide polymorphisms (SNPs) in the control region of the mitochondrial (mt) chromosome. With two alleles and three genotypes, PV92 is a simple genetic system that illustrates Mendelian inheritance on a molecular level. PV92 data is readily analyzed using population statistics. The mt control region is one of the simplest regions of human DNA to sequence. With a high mutation rate, the mt control region is the "classical" system for studying human and primate evolution. The Genetic Origins site and linked Bioservers site have all the information needed for students to perform the Alu and mt DNA experiments and analyze the results - including online protocols, reagents, animations and videos explaining key concepts, and database tools.

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Subject:
Genetics
Material Type:
Activities and Labs
Simulations
Provider:
Cold Spring Harbor Laboratory
Provider Set:
Dolan DNA Learning Center
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Incorporating Original Genomics Research into Genetics and Molecular Biology Courses
Conditions of Use:
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Incorporating Original Genomics Research into Genetics and Molecular Biology Courses
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Genomics and bioinformatics have revolutionized biology over the past few years, but ...

Genomics and bioinformatics have revolutionized biology over the past few years, but their impact on education has lagged. A new revolution is possible in the undergraduate curriculum. We have found novel ways to incorporate genomics research into the laboratory components of several courses. In this chapter, we show how we accomplish the typical skill development goals in a genetics or molecular biology course while accomplishing novel research, and provide the protocols for three such research projects that can be modified to suit the course goals or the instructor's research interests.

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Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Brad Goodner
Kathy Wheeler
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Translational Bioinformatics
Conditions of Use:
No Strings Attached
Translational Bioinformatics
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'Translational Bioinformatics' is a collection of articles which reads as a "book" ...

'Translational Bioinformatics' is a collection of articles which reads as a "book" to be used as a reference or tutorial for a graduate level introductory course on the science of translational bioinformatics. Translational bioinformatics is an emerging field that addresses the current challenges of integrating increasingly voluminous amounts of molecular and clinical data. Its aim is to provide a better understanding of the molecular basis of disease, which in turn will inform clinical practice and ultimately improve human health. The concept of a translational bioinformatics introductory book was originally conceived in 2009 by Jake Chen and Maricel Kann. Each chapter was crafted by leading experts who provide a solid introduction to the topics covered, complete with training exercises and answers. The rapid evolution of this field is expected to lead to updates and new chapters that will be incorporated into this collection.

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Subject:
Health, Medicine and Nursing
Information Science
Material Type:
Data
Primary Source
Provider:
Public Library of Science
Provider Set:
Computer & Information Sciences
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Computational Biology: Genomes, Networks, Evolution, Fall 2008
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Computational Biology: Genomes, Networks, Evolution, Fall 2008
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" This course focuses on the algorithmic and machine learning foundations of ...

" This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include: Genomes: biological sequence analysis, hidden Markov models, gene finding, RNA folding, sequence alignment, genome assembly Networks: gene expression analysis, regulatory motifs, graph algorithms, scale-free networks, network motifs, network evolution Evolution: comparative genomics, phylogenetics, genome duplication, genome rearrangements, evolutionary theory, rapid evolution "

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Subject:
Biology
Statistics and Probability
Material Type:
Activities and Labs
Assessments
Full Course
Homework and Assignments
Lecture Notes
Provider:
M.I.T.
Provider Set:
M.I.T. OpenCourseWare
Author:
Galagan, James
Kellis, Manolis
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Introduction to Bioinformatics (Slides with Voiceover)
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Introduction to Bioinformatics (Slides with Voiceover)
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This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides ...

This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides and DNA. The presentation then explains what bioinformatics is, lists some examples, and demonstrates some tools. It demonstrates tools which compare parts of human and chimp genes, and illustrate drug resistance analysis and HIV subtype analysis. It then discusses some ethical and clinical aspects to bioinformatics.

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Material Type:
Textbooks
Provider:
Global Health Informatics Partnership (GHIP)
OER Africa
Author:
Singh, Yashik
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Introduction to Bioinformatics Audio Only
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Introduction to Bioinformatics Audio Only
Rating

This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides ...

This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides and DNA. The presentation then explains what bioinformatics is, lists some examples, and demonstrates some tools. It demonstrates tools which compare parts of human and chimp genes, and illustrate drug resistance analysis and HIV subtype analysis. It then discusses some ethical and clinical aspects to bioinformatics.

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Material Type:
Textbooks
Provider:
Global Health Informatics Partnership (GHIP)
OER Africa
Author:
Singh, Yashik
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Introduction to Bioinformatics (Video Only)
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Introduction to Bioinformatics (Video Only)
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This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides ...

This HIBB presentation provides background information on bases, amino acids, proteins, nucleotides and DNA. The presentation then explains what bioinformatics is, lists some examples, and demonstrates some tools. It demonstrates tools which compare parts of human and chimp genes, and illustrate drug resistance analysis and HIV subtype analysis. It then discusses some ethical and clinical aspects to bioinformatics.

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Material Type:
Textbooks
Provider:
Global Health Informatics Partnership (GHIP)
OER Africa
Author:
Singh, Yashik
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Evolution Connection: DNA Replication
Conditions of Use:
Read the Fine Print
Evolution Connection: DNA Replication
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This short slide set explains the fidelity of DNA replication in evolutionary ...

This short slide set explains the fidelity of DNA replication in evolutionary terms. Save the slide set to your computer to view the explanation and notes that go along with each slide.

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Subject:
Biology
Genetics
Material Type:
Images and Illustrations
Lecture Notes
Teaching and Learning Strategies
Provider:
National Center For Science Education
University of California Museum of Paleontology
Provider Set:
Understanding Evolution
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