Search Results (202)

Save

Please log in to save materials.

View
Selected filters:
  • Molecular Biology
Creating Embryonic Stem Cell Lines
Conditions of Use:
Read the Fine Print
Rating

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can ... More

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells. Less

More
Subject:
Biology
Material Type:
Images and Illustrations
Readings
Simulations
Video Lectures
Provider:
Howard Hughes Medical Institute
Provider Set:
Howard Hughes Medical Institute
Less
Criminalistics in the Classroom
Conditions of Use:
Read the Fine Print
Rating

Crimes are written in the first semester by the upperclass students. Creative ... More

Crimes are written in the first semester by the upperclass students. Creative writing and good detective skills are combined in creating such past fictitious, nonviolent, crimes as "The Missing Snow Penguin," "Who Stole the Altar Wine" and "Vicious Valedictorian." Evidence was then collected including trace evidence such as hair, dirt and fibers, fingerprints, objects of clothing, pseudoblood samples, tool marks and impressions and handwriting samples. These objects were stored along with a preliminary police report in an Evidence Box. The suspected criminals in these cases are usually the faculty who generously allow themselves to be mug shot, fingerprinted and described freely as intellectual criminals. During the second semester underclass students solve these crimes motivated by the sheer sense of discovery. They are required to research tools and techniques of the criminalist and perform laboratory analyses to pinpoint the perpetrators. Less

More
Subject:
Education
Life Science
Chemistry
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Carolyn Rost (Mother of Mercy High School REV)
Permissions Manager (Access Excellence @ the National Health Museum REV)
Less
Cytoplasmic Factors
Conditions of Use:
Read the Fine Print
Rating

Cytoplasmic factors play a significant part in determining how a cell develops. ... More

Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development. Less

More
Subject:
Biology
Material Type:
Images and Illustrations
Readings
Simulations
Video Lectures
Provider:
Howard Hughes Medical Institute
Provider Set:
Howard Hughes Medical Institute
Less
DNA Biotechnology
Conditions of Use:
Read the Fine Print
Rating

This series involves a simulation of restriction enzyme activity and gel electrophoresis ... More

This series involves a simulation of restriction enzyme activity and gel electrophoresis and two DNA labs from Carolina Biological. Less

More
Subject:
Education
Life Science
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Peggy Campbell (Melbourne High School REV)
Permissions Coordinator (Access Excellence @ the National Health Museum REV)
Less
DNA Detectives
Conditions of Use:
Read the Fine Print
Rating

Many of the revolutionary changes that have occurred in biology since 1970 ... More

Many of the revolutionary changes that have occurred in biology since 1970 can be attributed directly to the ability to manipulate DNA in defined ways. The principal tools for this recombinant DNA technology are enzymes that can "cut and "paste" DNA. Restriction enzymes are the "chemical scissors" of the molecular biologist; these enzymes cut DNA at specific nucleotide sequences. A sample of someone's DNA, incubated with restriction enzymes, is reduced to millions of DNA fragments of varying sizes. A DNA sample from a different person would have a different nucleotide sequence and would thus be enzymatically "chopped up" into a very different collection of fragments. We have been asked to apply DNA fingerprinting to determine which suspect should be charged with a crime perpetrated in our city. Less

More
Subject:
Education
Life Science
Material Type:
Activities and Labs
Assessments
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Permissions Manger (Access Excellence @ the National Health Museum REV)
Suzanne Black (Inglemoor High School REV)
Less
DNA Dry Lab
Conditions of Use:
Read the Fine Print
Rating

This paper, pencil and scissors lab illustrates how the order of nucleotides ... More

This paper, pencil and scissors lab illustrates how the order of nucleotides in DNA determines the order of amino acids in proteins. It reinforces the concept that any change in the order of nucleotides can change the order of amino acids in proteins. Questions allow students to work through excercise at their own pace without missing key points. Less

More
Subject:
Education
Life Science
Material Type:
Activities and Labs
Instructional Material
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Permissions Manager (Access Excellence @ the National Health Museum REV)
Susan Offner (Milton High School REV)
Less
DNA Isolation from Onion
Conditions of Use:
Read the Fine Print
Rating

Many students find studying DNA difficult because it is so small that ... More

Many students find studying DNA difficult because it is so small that the concepts are quite abstract. This lab enables students to work with DNA concretely by easily isolating chromosomal DNA using the same basic tools and methods that scientists use. The lab is a good introduction to using pipets and to using the metric system. If the chemistry of the solutions is taught it is also a great practical application. Less

More
Subject:
Education
Life Science
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Kate Dollard (Cambridge Rindge and Latin REV)
Less
DNA Jewelry Models
Conditions of Use:
Read the Fine Print
Rating

Making DNA Jewelry Models is a portion of a unit on molecular ... More

Making DNA Jewelry Models is a portion of a unit on molecular genetics. Using the directions for this hands-on activity/lab helps students construct a model of DNA to learn DNA structure and decode it to better understand protein synthesis. They also have an actual badge of their DNA literacy to wear or use. Whether a key ring, earrings, bracelet, or necklace, students from fourth grade through adult can do and enjoy this activity. (Even visually impaired students made a model using larger beads.) Less

More
Subject:
Education
Life Science
Genetics
Chemistry
Anthropology
Material Type:
Activities and Labs
Data
Instructional Material
Lesson Plans
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Science and Math Informal Learning Educators (SMILE)
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
SMILE Pathway: Science and Math Activities in One Search
Author:
Access Excellence @ the National Health Museum REV
Catherine Ross
Catherine Sheils Ross (Berkley High School (retired-6/98) REV)
National Health Museum
Permissions Manager (Access Excellence @ the National Health Museum REV)
Less
DNA Microarrays: Background, Interactive Databases, and Hands-on Data Analysis
Conditions of Use:
Read the Fine Print
Rating

DNA microarrays are influencing many areas of biology. DNA microarrays allow investigators ... More

DNA microarrays are influencing many areas of biology. DNA microarrays allow investigators to measure simultaneously the activity of every gene in a genome. This paper provides the reader with background information, a set of interactive questions, and most importantly, free software (MAGIC Tool) for use in the undergraduate curriculum. MAGIC Tool (www.bio.davidson.edu/MAGIC) resources allow the user to understand how DNA microarray data are analyzed by providing raw data, instructions, mathematical supplements, and free software that works on all computer platforms. MAGIC Tool facilitates the incorporation of microarrays into any upper level biology course. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
A. Malcolm Campbell
Laurie Heyer
Less
DNA Profiling by Mutliplex PCR Amplification and Genotype Determination by Reverse Dot-Blot Hybridization to Sequence-Specific Oligonucleotide Probes
Conditions of Use:
Read the Fine Print
Rating

Human DNA profiling has applications in paternity testing and forensics. This exercise ... More

Human DNA profiling has applications in paternity testing and forensics. This exercise provides students the opportunity to gain first-hand experience with procedures that are currently used to extract DNA from their own cells, quantify the DNA in the extract, perform a multiplex PCR amplification of several loci used in forensic analysis, and determine their own genotype at those loci. In addition, methods for analyzing results relative to existing population databases will be presented. The exercise is normally presented in the context of a laboratory course in Forensic DNA Analysis that presents students with a variety of techniques that have been and/or continue to be employed in forensic laboratories. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Ralph Rascati
Less
DNA Sequencing Used to Illustrate Mutations and Evolution
Conditions of Use:
Read the Fine Print
Rating

This workshop, which is half wet lab and half Internet lab, uses ... More

This workshop, which is half wet lab and half Internet lab, uses DNA sequences to examine the relatedness of different species. DNA from several insect and/or fish species are compared. This chapter includes instructions for extracting DNA from gels and making PCR products. We prepare PCR products to send to a computerized automated sequencing facility. (No radioisotopes are used in this sequencing!) We recover sequence from the facility over the Web as four-color graphics on a computer screen and as text. We make pair-wise DNA sequence comparisons between species with BLAST2 and multi-species comparisons with MultAlin. We see substitutions, insertions, and deletions. Then we make a distance-based evolutionary tree with GeneBee. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Kathleen A. Nolan
Russell LeMon
Theodore Gurney
Less
Decoding the Flu
Conditions of Use:
Read the Fine Print
Rating

This "clicker case" was designed to develop students' ability to read and ... More

This "clicker case" was designed to develop students' ability to read and interpret information stored in DNA. Making use of personal response systems ("clickers") along with a PowerPoint presentation, students follow the story of "Jason," a student intern at the Centers for Disease Control& Prevention (CDC). While working with a CDC team in Mexico, Jason is the only person who does not get sick from a new strain of flu. It is up to Jason to use molecular data collected from different local strains of flu to identify which one may be causing the illness. Although designed for an introductory biology course for science or non-science majors, the case could be adapted for upper-level courses by including more complex problems and aspects of gene expression, such as the excision of introns. Less

More
Subject:
Life Science
Material Type:
Case Study
Instructional Material
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Norris Armstrong
Less
Detection of Genetically Modified Foods
Conditions of Use:
Read the Fine Print
Rating

Genetically modified foods are often in the news and widely grown in ... More

Genetically modified foods are often in the news and widely grown in the United States. Three US government agencies (USDA, FDA, and EPA) work to regulate the introduction and production of genetically modified foods. These crops can provide agricultural, ecological and nutritional benefits, but there are also potential risks to the environment and consumers. As consumers and public interest groups around the world have become aware of these risks, there has been a call for more explicit product labeling and reliable methods for the detection of genetic modification in the foods we eat. This lab activity explores these issues by taking students through a three-part process to detect the presence of genetic modification in corn (maize) or soy food products. This lab uses one of the two methods for detection of genetic modification currently approved by the European Union. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Diana Brandner
Less
Do You Really Know What You're Eating?: A Case Study on Genetically Modified Foods
Conditions of Use:
Read the Fine Print
Rating

Starting from a fictional "news" report about an apparent allergic reaction to ... More

Starting from a fictional "news" report about an apparent allergic reaction to a taco tainted by genetically modified corn, students consider some of the techniques and procedures used in modern molecular genetics and microbiology as well as some of the issues associated with genetically modified organisms (GMOs). Originally designed for role-play and PowerPoint assignments, suggestions for a shortened version are also provided. Suitable for a general microbiology course, the case could also be used in an introductory molecular biology course with appropriate modifications. Various levels of coverage of the topic of recombinant DNA are possible. Less

More
Subject:
Education
Life Science
Ecology
Forestry and Agriculture
Material Type:
Case Study
Instructional Material
Provider:
National Center for Case Study Teaching in Science
Provider Set:
Case Study Collection
Author:
Mary Celeste Reese
Wayne Shew
Less
Enzymes Basic Concepts and Kinetics  (Interactive Animation)
Conditions of Use:
Remix and Share
Rating

Enzymes are highly specific, powerful catalysts of biological systems that help to ... More

Enzymes are highly specific, powerful catalysts of biological systems that help to accelerate reactions taking place in organisms by factors of millions or more. Less

More
Subject:
Engineering
Biology
Chemistry
Material Type:
Interactive
Provider:
Indian Institute of Technology Bombay
Provider Set:
Project OSCAR
Author:
Harini Chandra,Prof. Sanjeeva Srivastava
Less
Enzymes Catalytic and Regulatory Strategies  (Interactive Animation)
Conditions of Use:
Remix and Share
Rating

Binding of a substrate to an enzyme catalytic site brings about conformational ... More

Binding of a substrate to an enzyme catalytic site brings about conformational changes in the enzyme with multiple weak interactions being formed with the substrate molecule. The amino acid side chains of the enzyme aid in cleavage and formation of bonds thereby providing a variety of mechanisms for catalysis to occur. Less

More
Subject:
Engineering
Biology
Chemistry
Material Type:
Interactive
Provider:
Indian Institute of Technology Bombay
Provider Set:
Project OSCAR
Author:
Harini Chandra,Prof. Sanjeeva Srivastava
Less
Examining Genetic Diversity in Disjunct Populations using Random DNA Markers
Conditions of Use:
Read the Fine Print
Rating

Molecular biological techniques are used to study naturally occurring genetic variation, and ... More

Molecular biological techniques are used to study naturally occurring genetic variation, and have greatly facilitated the understanding of problems in many areas of biology. In this lab, we examine two populations of terrestrial isopods in the Family Armadillidiidae using Random Amplification of Polymorphic DNA (RAPD Analysis). RAPDs are robust and generally species-independent. Using this technique, we are able to detect and analyze genetic variation within and between two different populations of isopods. This lab exercise could easily be modified for use in an introductory course for majors or non-majors and would be suitable for any organism with low vagility. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Association for Biology Laboratory Education (ABLE)
Author:
Judith A. Guinan
Robert Sheehy
Less
Experimental Molecular Neurobiology, Fall 2006
Conditions of Use:
Remix and Share
Rating

Designed for students without previous experience in techniques of cellular and molecular ... More

Designed for students without previous experience in techniques of cellular and molecular biology, this class teaches basic experimental techniques in cellular and molecular neurobiology. Experimental approaches covered include tissue culture of neuronal cell lines, dissection and culture of brain cells, DNA manipulation, synaptic protein analysis, immunocytochemistry, and fluorescent microscopy. Less

More
Subject:
Biology
Material Type:
Activities and Labs
Full Course
Homework and Assignments
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Hayashi, Yasunori
Less
Experimental demonstration that DNA is the genetic material
Conditions of Use:
Read the Fine Print
Rating

Two closely related strains of the bacterium Streptococcus pneumoniae differ from each ... More

Two closely related strains of the bacterium Streptococcus pneumoniae differ from each other both in their appearance under the microscope and in their pathogenicity. One strain appears smooth (S) and causes death when injected into mice, and the other appears rough (R) and is nonlethal. The experiment in (A) shows that a substance present in the S strain can change (or transform) the R strain into the S strain and that this change is inherited by subsequent generations of bacteria. The experiment in (B) identifies the substance as DNA. Less

More
Subject:
Education
Life Science
Mathematics
Chemistry
Material Type:
Images and Illustrations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Alexander Johnson
Bruce Alberts
Dennis Bray
Garland Publishing REV
Julian Lewis
Keith Roberts
Martin Raff
Peter Walter
Less