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3D FractaL-Tree
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3D FractaL-Tree allows scientists to collect data from actual specimens in the field or laboratory, insert these measurements into a spatially explicit L-system package, and then visually compare to the computer generated 3D image with such specimens. The measurements are recorded and analyzed in a series of worksheets in Microsoft Excel퉌Ź and the results are entered into the graphics engine in a Java applet. 3D FractaL-Tree produces a rotatable three-dimensional image of the tree which is helpful for examining such characters as self-avoidance (entanglement and breakage), penetration of sunlight, distances that small herbivores (such as caterpillars) would have to traverse to go from one tip to another, and Voronoi polyhedra of volume distribution of biomass on different subsections of a tree. These and other factors have been discussed in the Adaptive Geometry of Trees (Horn, 1971). Three different representations are available in 3D FractaL-Tree images: wire frame, solid, and transparent. Easy options for saving and exporting images are included.

Subject:
Biology
Material Type:
Activity/Lab
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The Biological ESTEEM Collection
Author:
Jennifer Spangenberg
John Jungck
Jutarat Maneewattanapluk
Noppadon Khiripet
Rawin Viruchpinta
3D FractaL-Tree
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This interactive L-system simulation produces visualizations of tree forms based on data from specimens in the field or laboratory.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Jennifer A Spangenberg
John R. Jungck
Jutarat Maneewattanapluk
Noppadon Khiripet
Rawin Viruchpinta
Action Potential Experiments
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Action Potential Experiments is a demonstration/simulation laboratory for neurophysiology based on the 'sodium theory' as originally formulated and tested by A. L. Hodgkin and his colleagues. The application includes simulations of the original experiments of Hodgkins and his colleagues, and of the classic voltage clamp and patch clamp experiments and an animated illustration of the 'sodium theory' explanation of Nernst potentials for potassium and sodium ions. The student can perform simple ion concentration experiments to test the predictions of the theory.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Mark Bergland
Aquaporins: Are regions of the protein conserved?
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The osmotic controlled passage of polar water through fundamentally nonpolar biologic lipid bilayers (membranes) wasn't understood until the work of Peter Agre and Roderick MacKinnon on aquaporins resulting in the Nobel prize in Chemistry in 2003. We decided to examine conservation in aquaporins. A Google search provided us with both the PDB id (1h6i) of the human aquaporin A chain from RBCs, and a clearer understanding that the aquaprorins represent a related group of proteins present in multiple species. At http://www.rcsb.org/pdb/ we conducted an initial investigation of the structure of 1h6i. At consurf (http://consurf.tau.ac.il/) we were able to obtain the protein sequences for the best 20 matches in nearly FASTA form. After text editing we ran Clustalw and retrieved both rooted and unrooted trees. In the trees, it is easy to see the families of aquaporins (type 1, 2 etc; see tree.doc below).

Subject:
Biology
Material Type:
Activity/Lab
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Bedrock
Author:
Gary Mort
Jerry Hall
Kathleen Morrison-Graham
Avida-ED
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Avida-ED allows users to design and perform experiments to test hypotheses about evolutionary mechanisms using evolving digital organisms. Avida-ED is an NSF-funded project to develop a digital evolution educational software platform for use in biology courses. The co-PIs on the project are Charles Ofria, Richard Lenski, and Diane Ebert-May. There are several on-line tools to help with problems with the Avida-ED program

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Robert T Pennock
BIRDD: Beagle Investigations Return with Darwinian Data
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BIRDD is a rich collection of primary scientific data and supporting materials about the Gal·pagos Islands and Darwin's finches.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Frank Price
Jim Stewart
John R. Jungck
Sam Donovan
BeeVisit
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BeeVisit enables students to evaluate the relative contributions of different pollinator species to a plant's reproductive success through an interactive model of pollen transfer.The model tracks a plant's presentation of pollen through time; pollen may be presented gradually or all at once, and the program lets you choose from a family of power curves to model the shape of the cumulative pollen presentation curve over a set number of time intervals (usually 100). Then, 'bees' of 1, 2, or 3 types are allowed to visit the plant.You specify the expected number and type of visits; this sets the probability of a visit occurring during each interval, and visits occur stochastically according to these probabilities.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Barbara Thomson James Thomson
BioGrapher
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PURPOSE: A simple Excel-based workbook with worksheets as a front end for the AT&T GraphViz Graph Layout software suite. BioGrapher enhances Excel-based tools developed in the Chemistry and Biology Departments at Beloit College to allow for convenient visualization of graphs and graphical connections that are importantin systems and computational biology, molecular biology, biochemistry, and genetics.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Rama ViswanathanHan LaiHlaing LinKhalid QumsiehJohn R. Jungck
BioGrapher: Graph Theoretical Properties and Visualization of Biological Interactions
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BioGrapher is an Excel front-end for the AT&T GraphViz graphical visualization and layout package (http://www.graphviz.org/). BioGrapher is unique in that it (1) allows users to enter data into an Excel spreadsheet in one of three ways: adjacency matrices, nodal lists, and Newick format for phylogenetic trees; (2) displays graphs in four different layouts: radial, circular, hierarchical, and tree; (3) properties of graphs, e.g., diameter, connectedness, and average clustering can be computed and displayed; (4) data can be read from standard comma separated value (CSV) text files. A VBA custom menu interface for the Windows and Mac OS X versions of GraphViz has been programmed and added to the standard Excel menu bar so that the user can easily invoke the graphical layout and computation routines.

Subject:
Biology
Material Type:
Activity/Lab
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The Biological ESTEEM Collection
Author:
Han Lai
Hlaing Lin
John Jungck
Khalid Qumsieh
Rama Viswanathan
BioQUEST's 3P's Approach to Science Education
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This site from BioQuest briefly explains how scientific knowledge is created, modified, and used. By using problem posing, problem solving and peer persuasion, students will experience science from the point of view of a practicing biologist.

Subject:
Biology
Material Type:
Lesson
Provider:
BioQUEST Curriculum Consortium
Author:
Beloit College
BioQUEST Curriculum Consortium
Biological Cellular Automata Laboratory (BioCA Lab)
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This module includes both linear cellular automata and 2D cellular automata. For linear CA, users can choose from a set of popular rules or define their own. For 2D CA, examples of a toroidal, cylindrical, and walled spatial configurations are presented, with a library of preset patterns and the ability to customize patterns. The original 3 rules for survival, death, and birth are implemented in this module, but users with some Excel퉌Ź knowledge can implement variations on these rules. Cellular automata have been extensively used in biology to model the development of pigmentation in textile cone shells, the spread of forest fires, and epidemics, for example.

Subject:
Biology
Material Type:
Activity/Lab
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The Biological ESTEEM Collection
Author:
Jennifer Spangenberg
John Jungck
Biometrics
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This text manual introduces statistical analysis and its underlying philosophy, enabling students to understand how to describe the confidence they have in their analysis.Statistical analysis is one of the most widely used, and abused, techniques in the biological sciences. Statistics are ostensibly used to allow an investigator to be objective. That is, the researcher uses statistical tests to determine whether or not his/her hypothesis is supported by the data collected.Unfortunately, the choice of the particular statistical test is often not objective and the underlying limitations of individual tests are often ignored or unknown by the researcher. Yet statistical analysis, when appropriately applied, allows scientists to examine the probability that their hypotheses are or are not supported by the data collected.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Dan Hornbach
Biosphere 2: Unexpected Interactions
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The Biosphere 2 project of the early 1990s failed dramatically because the planners overlooked the metabolic activities of naturally occurring soil microorganisms. The simulation program SimBio 2 allows us to gain insights into the complexity of this closed ecosystem. Here we can manipulate and monitor variables within a virtual Biosphere 2. We will explore oxygen availability by taking a closer look at the relationship between organic materials and living microbial populations in the soil. Alternative models can be constructed and simulated. * run simulations of a model of the Biosphere 2 to explore the unexpected impact of microbial metabolism on closed system dynamics

Subject:
Biology
Material Type:
Activity/Lab
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Microbes Count!
Author:
Ethel D. Stanley
Bioterror and the Microbiologistí˘ŒóŒťs Response
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The discovery of anthrax spores in the Senate Office Building in Washington in October 2001 as well as in several post offices caught microbiologists unprepared for their central role in the War on Terrorism. Infection control specialists were challenged to think of new strategies to confront the anthrax problem. How would you respond to this crisis? * develop a plan to decontaminate areas in the Senate Office Building where anthrax spores have been found

Subject:
Biology
Material Type:
Activity/Lab
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Microbes Count!
Author:
Marion Fass
Bumpus English Sparrow Data
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Data on multiple features of 136 freezing English sparrows of which 72 survived and 64 died. umpus, H. C. 1899. The elimination of the unfit as illustrated by the introduced sparrow, Passer domesticus. Biology Lectures, Marine Biological Lab. Woods Hole: 209-226.

Subject:
Biology
Material Type:
Data Set
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Numbers Count!
Author:
Frank Price
Caffeine and Water Quality: A Case-Based Biology Lesson Plan
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In this case, students will addresses such questions as: How does caffeine get into rivers? What are the effects of caffeine on the food species? Should we do anything about caffeine in our river? After completing the case, students will be able to: (1) identify field-collected invertebrates (at least to phylum); describe physiological differences and similarities across the invertebrate phyla in selected organism system/systems, and summarize and report potential impacts of a new environmental pollutant (caffeine) to an authority.

Subject:
Biology
Material Type:
Activity/Lab
Case Study
Diagram/Illustration
Lesson Plan
Provider:
BioQUEST Curriculum Consortium
Provider Set:
LifeLines Online
Author:
Kiser, Stacey
Cailliet Rockfish Depth vs. Age Data
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Age and depth data for 45 species of rockfish in the genus Sebastes. Cailliet GM, Andrews AH, Burton EJ, Watters DL, Kline DE, Ferry-Graham LA. Age determination and validation studies of marine fishes: do deep-dwellers live longer? Exp Gerontol. 2001 Apr;36(4-6):739-64.

Subject:
Biology
Material Type:
Data Set
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Numbers Count!
Author:
Anna Decker
Cardiovascular Construction Kit
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The Cardiovascular Construction Kit (CVCK) allows students to design and construct a wide range of cardiovascular systems, testing each one to see how it behaves and whether it could actually exist and survive in a real organism. CVCK provides a set of basic components, e.g., pumps, vessels, capillaries and so on, which may be pieced together to construct a cardiovascular system. Gauges and measurement techniques are provided so you can draw conclusions from your experiments. Note: CVCK is a MAC Archive Module and requires System 6.05 to System 6.07.To construct cardiovascular systems with CVCK, select components from the menu bars, drag them onto the main screen, and connect them together by making them touch.CVCK makes it possible to construct experiments as well as systems. Such experiments allow comparisons of the performance of systems with different configurations or characteristics.One constructs experiments by deciding what aspects of performance need to be measured and by hooking up gauges at appropriate places.Gauges that can measure variables like pressure and blood flow can be connected to the components, and the values that are read from these gauges can be displayed in the form of a graph.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Daniel Udovic
Nils Peterson
Sarah Douglas
Cardiovascular Function Lab
Conditions of Use:
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The CFL simulation includes two models: the original Isolated Heart Lab, which models an isolated left ventricle, and a new Closed Circulation LabThe <i>Closed Circulation Lab</i> models the entire circulatory loop: left ventricle, peripheral circulation, right ventricle, and pulmonary circulation.Both models include numerous input parameters that can be controlled by the user. Some of these parameters are shown in Figures 1 and 2. By manipulating these physiological variables, students can design experiments to investigate a variety of questions concerning how changes affect the performance of the heart.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Edward N Crawford
Nils Peterson
Case It
Conditions of Use:
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This software can be used to investigate common molecular biology laboratory procedures using DNA or protein sequence data. These simulations and cases are based primarily on genetic and infectious disease with techniques such as: DNA electrophoresis, Southern blot, PCR, Multiplex PCR, Dot blot, ELISA, Western blot, 96-well PCR, protein electrophoresis.Case It! is collaborative BioQUEST project between the University of Wisconsin-River Falls and Michigan State University.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Karen Klyczek
Mark Bergland
A Case on Invasive Species and Control: A Case-Based Biology Lesson Plan
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In this case-based learning activity, students will: develop an understanding of plant/animal interactions, communities, populations, and the impact of exotic, invasive species; engage in an ecological inquiry; be engaged in the use of science knowledge to make informed environmental policy decisions.

Subject:
Biology
Material Type:
Activity/Lab
Case Study
Diagram/Illustration
Lesson Plan
Provider:
BioQUEST Curriculum Consortium
Provider Set:
LifeLines Online
Author:
Rowe, Francie
Cell Differentials
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Cell Differentials offers a visual dataset of white blood cells that gives students practice in developing strategies and techniques for the recognition of these blood cell types. Over 100 different cell images are randomly presented with feedback on successful identification.In traditional labs, the recognition of white blood cell types can be compromised by several factors. Developmental changes can make recognition difficult and some cell types exhibit similar features. Microscopy can be a very individualistic kind of experience in which opportunities for instructor comments are often limited to spot checks of student comprehension. Cell Differentials was developed as a wet lab preface to provide students with abundant real-time feedback and tools to evaluate their own learning progress.

Subject:
Biology
Material Type:
Activity/Lab
Diagram/Illustration
Interactive
Lesson Plan
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
The BioQUEST Library Online
Author:
Deborah Clark
Donald Buckley
JoAnne Morrica
Karen Barrett
Lynn Gugliotti
Chimpanzee Conservation Problem Space
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Actively learn about chimpanzee conservation. The way it works: you ask your own questions, we give you tools to find credible answers and then you share your results for future users of this website.

Subject:
Biology
Material Type:
Activity/Lab
Lecture Notes
Teaching/Learning Strategy
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Bedrock
Author:
John Greenler
Chimpanzee Problem Space
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This problem space will allow you to actively learn about chimpanzee conservation. The way it works: you aks your own questions; we give you tools to find credible answers; and then you share your results for future users of this website.

Subject:
Biology
Material Type:
Activity/Lab
Reading
Teaching/Learning Strategy
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Bedrock
Citrus Canker: Alternatives for Control
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What do you do when county officials show up to cut down the orange trees in your backyard? What causes citrus canker and how is it spread? This plant pathogen was the first microbe to have its genome sequenced outside of the US. There is much to investigate before deciding on the best alternative for control. * examine international alternatives for the control of citrus canker

Subject:
Biology
Material Type:
Activity/Lab
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Microbes Count!
Author:
Ethel D. Stanley
Linda Weinland
Margaret Waterman
Peter Woodruff
Clinical Microbiology and Infectious Disease: A Case-Based Biology Lesson Plan
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After completing this case-based activity, students will be able to: draw conclusions based on disease symptoms and causative microorganisms; develop a strategy for collecting and handling samples; process samples in the laboratory; and identify laboratory steps used to reach an accurate identification of an organism.

Subject:
Biology
Material Type:
Activity/Lab
Case Study
Diagram/Illustration
Lesson Plan
Provider:
BioQUEST Curriculum Consortium
Provider Set:
LifeLines Online
Author:
Bishr, Mahmoud
Comparison of the Olfactory Receptor Genes in Canines and Primates
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Dogs are known for their acute sense of smell. Humans are not. Do dogs have a higher percentage of functional olfactory receptors as compared to humans and other primates? Students will be assigned to obtain the full length genetic sequence of five olfactory receptor (OR) genes from their assigned OR family. (See website below.) Students will determine if a functional orthologous gene is present in the human genome, in the genome of a great ape, and in the sequence of a monkey. The class will pool their data and analyze for the percentage of pseudogenes present in each group.

Subject:
Biology
Material Type:
Activity/Lab
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Bedrock
Author:
Brenda Whaley
Donald Frohlich
Gary Ogden
Jae-Ho Kim
Complements Please! No Compliments Necessary
Conditions of Use:
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Are mutant strains of bacteria that have the same nutritional phenotype identical? In the virtual MicroGCK lab, you can select colonies for further analysis to determine the underlying genetic structure of this similarity. This includes running a cross feeding complementation simulation for strains of nutritional auxotrophs. * investigate the genetic basis for phenotypic similarities in bacterial strains by simulating cross-feeding

Subject:
Biology
Material Type:
Activity/Lab
Simulation
Provider:
BioQUEST Curriculum Consortium
Provider Set:
Microbes Count!
Author:
John N. Calley
John R. Jungck