This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Neuromyelitis optica spectrum disorder, or NMOSD, is a rare auto-immune demyelinating disease of the central nervous system. Now considered a separate disorder from multiple sclerosis, NMOSD can be severely disabling and life-threatening, with a reported mortality of between 7 and 32%. The hallmark of the disease is recurrent attacks of optic neuritis and/or transverse myelitis that result in accumulating, irreversible disability, including blindness and paraplegia. Approximately 75 to 90% of patients with NMOSD have a disease-specific, pathogenic IgG autoantibody against the aquaporin-4 water channel, or AQP4. This antibody is thought to bind to AQP4 on astrocyte foot processes at the blood-brain barrier. This causes damage to astrocytes and the blood-brain barrier itself through several mechanisms, including the formation of the membrane attack complex through activation of the complement component C5b9..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Wet age-related macular degeneration, or wet AMD, occurs when newly formed blood vessels leak or bleed into the center of the retina, resulting in poor vision. Proactive treatment with intravitreal aflibercept has produced good outcomes in clinical studies. The treat-and-extend dosing strategy in particular has been shown to produce similar visual outcomes to fixed dosing every 4 or 8 weeks. And real-world evidence suggests that patients treated proactively in real life show outcomes similar to those observed in clinical trials. In the ALTAIR study, investigators explored how to fine-tune the proactive treat-and-extend approach in Japanese patients. The study aimed to identify the optimal extension interval for individual patients and individualize treatment with optimal extension to reduce the treatment burden for as many patients as possible. Ideally, treatments would be as infrequent as once every 16 weeks—with fast extensions made in 4-week increments—while maintaining initial vision gains..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This lesson includes procedures ensuring the full participation of students and staff with special needs and disabilities through the planning and implementation of preparedness, response and recovery strategies as part of the overall management of school bus emergencies and disasters with special needs students.Students with special needs are those who cannot comfortably or safely access and use the standard resources offered in disaster preparedness, relief and recovery, whether their disability is chronic or temporary.

Students are introduced to safety protocols by evaluating unsafe situations, sharing their ideas with their peers, developing a list of recommended safety protocols as a class, and finally, by comparing the class list to a standard list of safety rules. This activity seeks to demonstrate the importance of safety engineering and illustrate how it helps to prevent injuries and save lives. A PowerPoint® presentation, pre/post quiz and student handout are provided.

A new approach to safety, based on systems thinking, that is more effective, less costly, and easier to use than current techniques. Engineering has experienced a technological revolution, but the basic engineering techniques applied in safety and reliability engineering, created in a simpler, analog world, have changed very little over the years. In this groundbreaking book, Nancy Leveson proposes a new approach to safety—more suited to today's complex, sociotechnical, software-intensive world—based on modern systems thinking and systems theory. Revisiting and updating ideas pioneered by 1950s aerospace engineers in their System Safety concept, and testing her new model extensively on real-world examples, Leveson has created a new approach to safety that is more effective, less expensive, and easier to use than current techniques. Arguing that traditional models of causality are inadequate, Leveson presents a new, extended model of causation (Systems-Theoretic Accident Model and Processes, or STAMP), then shows how the new model can be used to create techniques for system safety engineering, including accident analysis, hazard analysis, system design, safety in operations, and management of safety-critical systems. She applies the new techniques to real-world events including the friendly-fire loss of a U.S. Blackhawk helicopter in the first Gulf War; the Vioxx recall; the U.S. Navy SUBSAFE program; and the bacterial contamination of a public water supply in a Canadian town. Leveson's approach is relevant even beyond safety engineering, offering techniques for “reengineering” any large sociotechnical system to improve safety and manage risk.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"According to a new study, the cholesterol-reducing drug evolocumab plus a moderate-intensity statin dose was effective in Chinese patients with both type 2 diabetes and hyperlipidemia or mixed dyslipidemia. China has the highest diabetes burden of any country in the world. And as is the case for Western populations, diabetes is a major risk factor for cardiovascular disease in Asian adults. The primary target for treating such patients is reducing low-density lipoprotein, or LDL, cholesterol. While statin therapy is recommended globally, research suggests that statin-related adverse reactions occur at higher rates among Chinese patients. The inability to achieve the recommended LDL levels in Chinese patients might therefore be related to statin intolerance or underuse of statins due to the risk of adverse events..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Diabetes is a major risk factor for myocardial infarction, stroke, and other cardiovascular diseases. The prime target for reducing cardiovascular risk is low-density lipoprotein, or LDL. LDL cholesterol has been linked to cardiovascular events in patients with type 2 diabetes. While statins have long been the primary treatment for reducing LDL, many patients are unable to reach recommended levels with a statin alone or are unable to take an effective dose. That places them at an especially high risk for cardiovascular disease. Now, a new study reports the efficacy and safety of evolocumab on top of statins in patients with both type 2 diabetes and hyperlipidemia or mixed dyslipidemia. The double-blind, phase 3 trial was conducted in patients from 10 different countries over a treatment period of 12 weeks. More than 980 patients were randomized to one of four subcutaneous treatments: 140 mg of evolocumab every 2 weeks, 420 mg of evolocumab monthly, or placebo at either of those frequencies..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource provides access to tips, tools, practice briefs, videos and courses relate to family time coaching in the field of child welfare and was compiled specifically for Northern California counties by the Northern California Training Academy. To learn more about the Academy, please visit www.humanservices.ucdavis.edu/academy

This video segment adapted from NOVA explains how the sprinkler revolutionized fire safety and also features developments in fire-safety design for high-rise buildings.

Urban governance comprises the various forces, institutions, and movements that guide economic and physical development, the distribution of resources, social interactions, and other aspects of daily life in urban areas. This course examines governance from legal, political, social, and economic perspectives. In addition, we will discuss how these structures constrain collective decision making about particular urban issues (immigration, education…). Assignments will be nightly readings and a short paper relating an urban issue to the frameworks outlined in the class.

This team-taught multidisciplinary course provides information relevant to the conduct and interpretation of human brain mapping studies. It begins with in-depth coverage of the physics of image formation, mechanisms of image contrast, and the physiological basis for image signals. Parenchymal and cerebrovascular neuroanatomy and application of sophisticated structural analysis algorithms for segmentation and registration of functional data are discussed. Additional topics include: fMRI experimental design including block design, event related and exploratory data analysis methods, and building and applying statistical models for fMRI data; and human subject issues including informed consent, institutional review board requirements and safety in the high field environment.
Additional Faculty
Div Bolar
Dr. Bradford Dickerson
Dr. John Gabrieli
Dr. Doug Greve
Dr. Karl Helmer
Dr. Dara Manoach
Dr. Jason Mitchell
Dr. Christopher Moore
Dr. Vitaly Napadow
Dr. Jon Polimeni
Dr. Sonia Pujol
Dr. Bruce Rosen
Dr. Mert Sabuncu
Dr. David Salat
Dr. Robert Savoy
Dr. David Somers
Dr. A. Gregory Sorensen
Dr. Christina Triantafyllou
Dr. Wim Vanduffel
Dr. Mark Vangel
Dr. Lawrence Wald
Dr. Susan Whitfield-Gabrieli
Dr. Anastasia Yendiki

Students combine art, gaming culture and engineering by fabricating light-up patches to increase youngsters’ visibility at night. The open-ended project is presented as a hypothetical design challenge: Students are engineers who have been asked by a group of parents whose children go out Pokémon hunting at night to create glowing patches that they adhere to clothing or backpacks to help vehicle drivers see the kids in the dark. Student pairs create Pokémon character stencil designs cut from iron-on fabric patches, adding transparent layers for color. Placed over an EL (electroluminescent) panel that is connected to a battery pack, the stencils create glowing designs. Each team creates a circuit, which includes lengthening the EL panel wiring to make it easier to wear. Then they sew/adhere the patches onto hoodies, messenger bags, hats, pockets or other applications they dream up. The project concludes with team presentations as if to an audience of project clients. Keep the project simple by hand cutting and ironing/sewing, or use cutting machines, laser cutters and sewing machines, if available.

This lesson introduces the MRI Safety Grand Challenge question. Students are asked to write journal responses to the question and brainstorm what information they will need to answer the question. The ideas are shared with the class and recorded. Students then watch a video interview with a real life researcher to gain a professional perspective on MRI safety and brainstorm any additional ideas. The associated activity provides students the opportunity to visualize magnetic fields.

Workplace injuries happen every day and can profoundly affect workers, their families, and the communities in which they live. This textbook is for workers and students looking for an introduction to injury prevention on the job. It offers an extensive overview of central occupational health and safety (OHS) concepts and practices and provides practical suggestions for health and safety advocacy. Foster and Barnetson bring the field into the twenty-first century by including discussions of how precarious employment, gender, and ill-health can be better handled in Canadian OHS.

In this interactive, learners develop the skills to handle a horse safely before entering the corral for the first time. The interactive consists of three stages, each explaining an aspect of the safety procedures necessary for leading a horse.

Learning ObjectivesFlorida is situated in what is known as the "hurricane alley." This region starts from the west coast of Africa to Florida, and up the Carolinas. This region is prone to tropical storms and hurricanes due to the warm water temperatures. The objective of this lesson is to offer tips and strategies without causing fear to elementary-level students so that students they can be prepared for the event of a hurricane ahead of time.

This short lesson is designed for middle school students (grades 6-8). It goes over a simple definition of the internet, it's risks, and ways to practice internet safety. There is also a short activity at the end to reflect on the subject and consider how it applies to the student. 

Offered in the spring and fall terms, Introduction to Stagecraft is a hands-on course that gets students working with the tools and techniques of theatrical production in a practical way. It is not a design course but one devoted to artisanship. Among the many remarkable final projects that have been proposed and presented at the end of the course have been a Renaissance hourglass blown in the MIT glass shop and set into a frame turned on our set shop lathe; a four harness loom built by a student who then wove cloth on it; a number of chain mail tunics and coifs; a wide variety of costume and furniture pieces and electrified period lighting fixtures.

Concerns about wind turbines causing bird deaths are often exaggerated. Data shows that bird fatalities from wind turbines are relatively low compared to other causes like domestic cats and building collisions. When assessing the relative impact on bird mortality, wind energy appears less harmful than many other forms of electricity generation.