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Biology, The Chemistry of Life, Biological Macromolecules, Proteins
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By the end of this section, you will be able to:Describe the functions proteins perform in the cell and in tissuesDiscuss the relationship between amino acids and proteinsExplain the four levels of protein organizationDescribe the ways in which protein shape and function are linked

Subject:
Applied Science
Biology
Life Science
Material Type:
Module
Date Added:
07/10/2017
Breakfast Proteins
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Construct a protein through cereal additions. Model the central dogma of molecular biology by constructing a colorful chain using a simple code (and some delicious cereal).

Subject:
Biology
Life Science
Material Type:
Activity/Lab
Provider:
Exploratorium
Provider Set:
Science Snacks
Date Added:
03/30/2018
Buffer Exchange methods overview
Unrestricted Use
CC BY
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If the dialysis is the most know method used for buffer exchange, other methods less as desalting and tangential flow filtrations can be useful to speed up or scale up the buffer exchange process.

Subject:
Education
Educational Technology
Material Type:
Lecture
Author:
Manuele Martinelli
Date Added:
09/21/2021
Computational Functional Genomics
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CC BY-NC-SA
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The course focuses on casting contemporary problems in systems biology and functional genomics in computational terms and providing appropriate tools and methods to solve them. Topics include genome structure and function, transcriptional regulation, and stem cell biology in particular; measurement technologies such as microarrays (expression, protein-DNA interactions, chromatin structure); statistical data analysis, predictive and causal inference, and experiment design. The emphasis is on coupling problem structures (biological questions) with appropriate computational approaches.

Subject:
Applied Science
Biology
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Gifford, David
Jaakkola, Tommi
Date Added:
02/01/2005
DNA: The Human Body Recipe
Read the Fine Print
Educational Use
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As a class, students work through an example showing how DNA provides the "recipe" for making our body proteins. They see how the pattern of nucleotide bases (adenine, thymine, guanine, cytosine) forms the double helix ladder shape of DNA, and serves as the code for the steps required to make genes. They also learn some ways that engineers and scientists are applying their understanding of DNA in our world.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Lesson Plan
Teaching/Learning Strategy
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Denise W. Carlson
Frank Burkholder
Jessica Todd
Malinda Schaefer Zarske
Date Added:
09/18/2014
A Day in the Life of a Protein
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Educational Use
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The goal of these lessons, packaged under the title “A Day in the Life of a Protein,” is to select an example that is not only real world, but also is connected to many of the topics taught in the course. The specific protein used here is Hemoglobin A, looking at the mutation leading to sickle cell anemia. Other proteins could be substituted into this model as needed.

Subject:
Biology
Life Science
Material Type:
Lesson Plan
Provider:
North Carolina State University
Provider Set:
Kenan Fellows Program for Curriculum and Leadership Development
Author:
Laura Stiles
Date Added:
03/03/2016
Gene Expression - The Basics
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CC BY
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Express yourself through your genes! See if you can generate and collect three types of protein, then move on to explore the factors that affect protein synthesis in a cell.

Subject:
Genetics
Life Science
Material Type:
Simulation
Provider:
University of Colorado Boulder
Provider Set:
PhET Interactive Simulations
Author:
Ariel Paul
George Emanuel
John Blanco
Kathy Perkins
Mike Klymkowsky
Tom Perkins
Date Added:
08/20/2012
Glowing Flowers
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Educational Use
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Student teams learn about engineering design of green fluorescent proteins (GFPs) and their use in medical research, including stem cell research. They simulate the use of GFPs by adding fluorescent dye to water and letting a flower or plant to transport the dye throughout its structure. Students apply their knowledge of GFPs to engineering applications in the medical, environmental and space exploration fields. Due to the fluorescing nature of the dye, plant life of any color, light or dark, can be used unlike dyes that can only be seen in visible light.

Subject:
Applied Science
Engineering
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Christie Chatterley
Janet Yowell
Malinda Schaefer Zarske
Date Added:
10/14/2015
Goodness Gracious! Great Balls of Gluten!
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This is an activity about a very important ingredient in most baked goods - gluten! Why is gluten so important? Without it, there would be nothing to hold the gas that makes bread rise. Learners will experiment with different types of flour to get a feel for gluten, and discover why using different flours can lead to such different results in the kitchen.

Subject:
Chemistry
Physical Science
Material Type:
Activity/Lab
Provider:
Exploratorium
Author:
Don Rathjen
Exploratorium
National Science Foundation
The Exploratorium
Date Added:
10/31/2012
High-temperature frying can produce toxic fumes, potentially causing respiratory problems
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"High-temperature frying might produce delicious food... But it also carries certain health risks One lesser-known risk is difficulty breathing New research published in the journal Indoor Air shows that high-temperature frying can generate harmful emissions Exposure to frying fumes can irritate the airways and lead to respiratory symptoms Researchers showed that the fumes produced from heating protein-rich foods to temperatures over 250°C (482°F) carry toxic compounds such as isocyanic acid These compounds are produced from the nitrogen found in amino acids Exposure to isocyanic acid can damage proteins found in the airways, potentially causing respiratory symptoms The good news is that the toxic constituents in frying fumes vary depending on cooking style, cooking temperature, and whether the food being cooked is protein-rich Protein-rich foods cooked at or below 200°C (390°F) generate very little of these toxic gases....."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider Set:
Video Bytes
Date Added:
09/20/2019
Homing in on how H pylori aids in the development of stomach cancer
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Residing in the stomachs of over half the human population, the bacterium Helicobacter pylori, also known as H pylori, has become a major cause of digestive complications, ranging from peptic ulcers to stomach cancer. But despite this link, scientists still aren’t sure how these disorders arise after infection. Now, researchers have homed in on a single protein produced by H pylori that seems to rev up the immune system, causing a state of inflammation that may pave the way for cancer growth or other types of gut breakdown. The protein, HP1454, is naturally released from H pylori -- both actively by living cells and passively as cells die. The scientists found that when special immune cells known as T cells encounter this secreted HP1454, they kick into action, mounting an inflammatory response. This relationship was particularly strong in people with stomach cancer..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Inside the DNA
Read the Fine Print
Educational Use
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Students conduct their own research to discover and understand the methods designed by engineers and used by scientists to analyze or validate the molecular structure of DNA, proteins and enzymes, as well as basic information about gel electrophoresis and DNA identification. In this computer-based activity, students investigate particular molecular imaging technologies, such as x-ray, atomic force microscopy, transmission electron microscopy, and create short PowerPoint presentations that address key points. The presentations include their own explanations of the difference between molecular imaging and gel electrophoresis.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Mircea Ionescu
Myla Van Duyn
Date Added:
09/18/2014
Introduction to Genetic Engineering and Its Applications
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Educational Use
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Students learn how engineers apply their understanding of DNA to manipulate specific genes to produce desired traits, and how engineers have used this practice to address current problems facing humanity. They learn what genetic engineering means and examples of its applications, as well as moral and ethical problems related to its implementation. Students fill out a flow chart to list the methods to modify genes to create GMOs and example applications of bacteria, plant and animal GMOs.

Subject:
Applied Science
Engineering
Genetics
Life Science
Material Type:
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Kimberly Anderson
Matthew Zelisko
Date Added:
09/18/2014
Life Size
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In this activity on page 1 of the PDF, learners compare the relative sizes of biological objects (like DNA and bacteria) that can't be seen by the naked eye. Learners will be surprised to discover the range of sizes in the microscopic world. This activity can be followed up with a second activity, "What's in a microbe?", located on page 3 in the same resource.

Subject:
Biology
Life Science
Material Type:
Activity/Lab
Provider:
Exploratorium
Author:
Julie Yu
National Science Foundation
The Exploratorium
Date Added:
11/07/2006
Lignocellulose digestion in Protaetia brevitarsis: a tightly designed microbial production line
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Domesticated edible insects are a sustainable protein source that has been gaining global attention. P. brevitarsis is one such species, and their larvae can also eat decaying organic waste and turn it into a plant-growth promoting mixture. But organic matter like this is high in lignocellulose, which is difficult to digest. In fact, these larvae lack the enzymes needed to break lignocellulose down on their own. So, researchers checked their microbiome for microbial genes able to fill in the gaps. The researchers established a comprehensive reference catalog of gut microbial and host genes. Between the two sets of genes, lignocellulose-degrading enzymes were abundant and highly diversified. P. brevitarsis larvae also selectively enriched their microbiome for lignocellulose-degrading microbes and had physiological adaptations that assisted in lignocellulose degradation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023
Molecular Structure of Biological Materials (BE.442)
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CC BY-NC-SA
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This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

Subject:
Applied Science
Biology
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Zhang, Shuguang
Date Added:
09/01/2005