Keywords: Structure Determination (4)

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The Impact of Structural Genomics: Expectations and Outcomes
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The Impact of Structural Genomics: Expectations and Outcomes

Structural genomics (SG) projects aim to expand our structural knowledge of biological ... (more)

Structural genomics (SG) projects aim to expand our structural knowledge of biological macromolecules while lowering the average costs of structure determination. We quantitatively analyzed the novelty, cost, and impact of structures solved by SG centers, and we contrast these results with traditional structural biology. The first structure identified in a protein family enables inference of the fold and of ancient relationships to other proteins; in the year ending 31 January 2005, about half of such structures were solved at a SG center rather than in a traditional laboratory. Furthermore, the cost of solving a structure at the most efficient SG center in the United States has dropped to one-quarter of the estimated cost of solving a structure by traditional methods. However, the efficiency of the top structural biology laboratoriesí˘ŒóŒîeven though they work on very challenging structuresí˘ŒóŒîis comparable to that of SG centers; moreover, traditional structural biology papers are cited significantly more often, suggesting greater current impact. (less)

Subject:
Life Science
Education
Material Type:
Data
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Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
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BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
John-Marc Chandonia (University of California;Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, and Department of Plant and Microbial Biology)
Steven E. Brenner (University of California;Berkeley Structural Genomics Center, Physical Biosciences Division, Lawrence Berkeley National Laboratory, and Department of Plant and Microbial Biology)
Organic Chemistry II, Fall 2003
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Organic Chemistry II, Fall 2003

Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure ... (more)

Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry included to illustrate the role of organic chemistry in biological systems and in the chemical industry. (less)

Subject:
Science and Technology
Material Type:
Activities and Labs
Assessments
Full Course
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Lecture Notes
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Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Jamison, Timothy
Tabacco, Sarah
Organic Chemistry II, Spring 2003
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Organic Chemistry II, Spring 2003

Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure ... (more)

Intermediate organic chemistry. Synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry included to illustrate the role of organic chemistry in biological systems and in the chemical industry. (less)

Subject:
Science and Technology
Material Type:
Assessments
Full Course
Homework and Assignments
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Swager, Timothy M.
System Identification, Spring 2005
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System Identification, Spring 2005

Mathematical models of systems from observations of their behavior. Time series, state-space, ... (more)

Mathematical models of systems from observations of their behavior. Time series, state-space, and input-output models. Model structures, parametrization, and identifiability. Non-parametric methods. Prediction error methods for parameter estimation, convergence, consistency, andasymptotic distribution. Relations to maximum likelihood estimation. Recursive estimation; relation to Kalman filters; structure determination; order estimation; Akaike criterion; and bounded but unknown noise models. Robustness and practical issues. (less)

Subject:
Science and Technology
Material Type:
Full Course
Homework and Assignments
Lecture Notes
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Dahleh, Munther
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