Keywords: Potassium (82)

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Allosteric Modulation of Ion Channels: The Case of Maxi-K
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Allosteric Modulation of Ion Channels: The Case of Maxi-K

Maxi-K channel gating is modulated by both membrane voltage and cytoplasmic Ca2+. ... (more)

Maxi-K channel gating is modulated by both membrane voltage and cytoplasmic Ca2+. Recent work has led to a quantitative understanding of this dual regulatory mechanism, derived from classical allosteric principles, in terms of the energetic coupling among membrane voltage, Ca2+ binding, and opening of the channel’s gate. Our new understanding of the gating pathway can be applied to the interpretation of mutagenesis experiments and may serve as an example in the analysis of other dually regulated signaling molecules. (less)

Subject:
Life Science
Material Type:
Activities and Labs
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Brad S. Rothberg (University of Texas Health Science Center;Department of Physiology REV)
A Balancing Act
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A Balancing Act

In this plant science activity, learners role play as vegetables and weeds ... (more)

In this plant science activity, learners role play as vegetables and weeds competing for nutrients. The object of the game is for the weeds and vegetables to gather as many colored squares as they can. Each paper square represents a different type of nutrient (i.e. green squares represent nitrogen). If a vegetable or a weed does not have at least two of each color square, they ‰ŰĎdie‰Ű from not getting enough nutrients and must step out of the garden. Use this activity to simulate survival and competition in nature and plant-life. (less)

Subject:
Science and Technology
Chemistry
Ecology
Forestry and Agriculture
Geoscience
Life Science
Technology
Social Sciences
Education
Material Type:
Activities and Labs
Games
Instructional Material
Lesson Plans
Simulations
Provider:
Science and Math Informal Learning Educators (SMILE)
Wisconsin 4-H Youth Development
Provider Set:
SMILE Pathway: Science and Math Activities in One Search
SMILE Pathway
Author:
4-H
University of Wisconsin Extension
Cardio Action Maze
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Cardio Action Maze

Web-based Action Maze: An action maze is an interactive problem solving activity. ... (more)

Web-based Action Maze: An action maze is an interactive problem solving activity. Students are presented with a situation and make choices that lead to another situation with a new set of options. Some choices may end up as 퉌ńdead-ends퉌î in the maze and require starting over, while others may offer alternative ways to move forward through the activity. Informative or 퉌ńreview퉌î options are occasionally offered along the way. This is a web-based (html format, accessible from any computer) tutorial type learning tool for students to use to review cardiovascular anatomy and physiology information they have already learned in class: sequence blood through chambers, to heart muscle & sequence electric stimulus reviewing anatomy; compare/contrast cardiac & skeletal muscle cells and three parts of ECG on Venn diagram; and analyze and interpret graphical presentation of information related to ECG & myograph action potentials of skeletal fibers, cardiac pace-maker cells & cardiac contractile. It provides an alternative way for the students to assess their content knowledge and apply it at higher cognitive levels (compare/contrast, interpret, evaluate, etc.) in a different way of being presented with the information from text reading and lecture. (less)

Subject:
Chemistry
Engineering
Life Science
Physics
Education
Material Type:
Activities and Labs
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Ms. Terry Thompson (Wor-Wic Community College Math/Science)
Cereal Magnets
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Cereal Magnets

In this activity, students will design a process that removes the most ... (more)

In this activity, students will design a process that removes the most iron from the cereal. This activity is meant for the students to experiment with different materials using what they know about iron, magnets, and forces to design the best process for removing the iron from the cereal. (less)

Subject:
Mathematics and Statistics
Science and Technology
Material Type:
Activities and Labs
Lesson Plans
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Liz Harper
Concept Map: Summary of Urinary System Function and Fluid/Electrolyte Balance
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Concept Map: Summary of Urinary System Function and Fluid/Electrolyte Balance

A concept map exercise to review processes of urine formation and fluid ... (more)

A concept map exercise to review processes of urine formation and fluid and electrolyte balance, and show how they inter-relate. (less)

Subject:
Chemistry
Geoscience
Life Science
Physics
Education
Material Type:
Activities and Labs
Assessments
Instructional Material
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Carol Gavareski (Bellingham Technical College Sciences)
Demonstration of temperature dependence of Na(+)-K+ pump activity of human blood cells
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Demonstration of temperature dependence of Na(+)-K+ pump activity of human blood cells

Laboratory experiment demonstrating the effect of temperature on blood ion distribution

Subject:
Chemistry
Geoscience
Life Science
Education
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Arnold Honig (Ernst-Moritz-Arndt University of Greifswald Institute of Physiology)
Christine Budweg (Ernst-Moritz-Arndt-University of Greifswald Physiology and Diabetes)
Ernst-Joachim Freyse (Ernst-Moritz-Arndt-University of Greifswald Institue of Physiology and Diabetes)
Heiko Goldbecher (Ernst-Moritz-Arndt-University of Greifswald Institute of Physiology and Diabetes)
Helga Oppermann (Ernst-Moritz-Arndt- Univeristy of Greifswald Institute of Physiology and Diabetes)
Dr. Bernice Grafstein퉌Ís paper on the mechanism of spreading depression
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Dr. Bernice Grafstein퉌Ís paper on the mechanism of spreading depression

Essay on APS Classic Paper by Grafstein on Mechanism of spreading cortical ... (more)

Essay on APS Classic Paper by Grafstein on Mechanism of spreading cortical depression (less)

Subject:
Chemistry
Life Science
Education
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Anthony J. Strong (King퉌Ís College London Department of Clinical Neurosciences)
Electrochemical Driving Force During Neuronal Action Potential (Nernst-AP)
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Electrochemical Driving Force During Neuronal Action Potential (Nernst-AP)

Computer simulations showing changes in electrochemical driving force and relative conductance during ... (more)

Computer simulations showing changes in electrochemical driving force and relative conductance during a neuronal action potential (less)

Subject:
Chemistry
Life Science
Physics
Education
Material Type:
Instructional Material
Simulations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
PhD Michael J. Davis (Texas A&M University Dept. of Medical Physiology)
Electrochemical Equilibrium (Nernst) Lab
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Electrochemical Equilibrium (Nernst) Lab

Computer simulation to illustrate how the concentrations of the major ionic species ... (more)

Computer simulation to illustrate how the concentrations of the major ionic species inside and outside a cell determine its resting membrane potential. (less)

Subject:
Chemistry
Life Science
Physics
Education
Material Type:
Activities and Labs
Instructional Material
Simulations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
PhD Michael J. Davis (Texas A&M University Dept. of Medical Physiology)
FXYD Proteins: New Tissue-Specific Regulators of the Ubiquitous Na,K-ATPase
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FXYD Proteins: New Tissue-Specific Regulators of the Ubiquitous Na,K-ATPase

The Na,K-ATPase is a plasma membrane enzyme that is responsible for maintaining ... (more)

The Na,K-ATPase is a plasma membrane enzyme that is responsible for maintaining the Na+ and K+ gradients between the intra- and extracellular milieu of animal cells. It consists of a catalytic α subunit and a regulatory β subunit. Na,K-ATPase transports Na+ out of the cell and K+ into the cell against their respective chemical gradients by using energy derived from the hydrolysis of ATP. Maintenance of the Na+ and K+ gradients by the Na,K-ATPase is essential for basic cellular homeostasis as well as for specialized functions of various tissues. Rigorous control of the Na+ and K+ gradients by Na,K-ATPase is necessary for preservation of cell volume, maintenance of membrane potential, and activity of secondary transporters that provide the cell with nutrients or regulate cellular solute concentrations. Moreover, in renal epithelial cells, the Na,K-ATPase, exclusively located in the basolateral membrane, is the driving force for the Na+ reabsorption that maintains extracellular volume and, hence, blood pressure. In addition, in heart and skeletal muscle, the activity of Na,K-ATPase is tightly coupled to the activity of a Na+/Ca2+-exchanger that controls muscle contraction. Finally, in the nervous system, Na,K-ATPase contributes to the re-establishment of the basal Na+ and K+ gradients both during action potentials and consequent to neuronal excitation. The Na,K-ATPase must be finely regulated to fulfil its important tasks under changing physiological conditions. Tissue-specific differences in Na,K-ATPase activity are achieved by the expression of four α and three β isoforms, which potentially can form 12 Na,K-ATPase isozymes with different functional properties. Moreover, various hormones and neurotransmitters are involved in the short- and long-term control of Na,K-ATPase; they regulate its activity and/or expression through protein kinase phosphorylation or transcriptional control. In this review, we discuss a novel regulatory mechanism of Na,K-ATPase that is mediated by the interaction of Na,K-ATPase with small membrane proteins of the FXYD family that so far have been considered as channels or regulators of ion channels. The FXYD proteins FXYD1 through FXYD7 exhibit tissue-specific distribution. FXYD1 (phospholemman) in heart and skeletal muscle, FXYD2 (the γ subunit of Na,K-ATPase) and FXYD4 [corticosteroid hormone-induced factor (CHIF)] in the kidney, and FXYD7 in the brain associate preferentially with the Na,K-ATPase α1-β1 isozyme and modulate its transport properties in a way that conforms to tissue-specific requirements. Thus, FXYD proteins contribute to proper handling of Na+ and K+ by the most widely expressed Na,K-ATPase α1-β1 isozymes, and ensure correct function in such mechanisms as renal Na+ reabsorption, muscle contraction, and neuronal excitability (less)

Subject:
Chemistry
Life Science
Material Type:
Activities and Labs
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Gilles Crambert (University of Lausanne;Institute of Pharmacology and Toxicology REV)
Kathi Geering (University of Lausanne;Institute of Pharmacology and Toxicology REV)
Fortified Breakfast
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Fortified Breakfast

In this lesson, students will learn that minerals are a necessary part ... (more)

In this lesson, students will learn that minerals are a necessary part of our diet. They will learn that different minerals have different functions in the body. More specifically, they will discover that iron is necessary to carry oxygen around the body. In the associated activity, students will design a process that removes the most iron from the cereal. (less)

Subject:
Mathematics and Statistics
Science and Technology
Chemistry
Ecology
Engineering
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Instructional Material
Lesson Plans
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Engineering K-PhD Program,
Liz Harper
TeachEngineering.org
Generation of Resting Membrane Potential
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Generation of Resting Membrane Potential

Refresher on the ideas associated with teaching students the physiological basis of ... (more)

Refresher on the ideas associated with teaching students the physiological basis of the resting membrane potential (less)

Subject:
Chemistry
Life Science
Education
Material Type:
Instructional Material
Lecture Notes
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
PhD Stephen H. Wright (University of Arizona College of Medicine Department of Physiology)
Generation of the Membrane Potential
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Generation of the Membrane Potential

PowerPoint presentation from APS 2004 Refresher Course

Subject:
Chemistry
Life Science
Education
Material Type:
Instructional Material
Lecture Notes
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
PhD Stephen H. Wright (University of Arizona College of Medicine Department of Physiology)
Glomeruli Filtration
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Glomeruli Filtration

Students will produce a physical model of the glomeruli filtration. This activity ... (more)

Students will produce a physical model of the glomeruli filtration. This activity is intended for a high school Anatomy and Physiology (grades 11-12) class. (less)

Subject:
Chemistry
Geoscience
Life Science
Physics
Education
Material Type:
Activities and Labs
Instructional Material
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Anika M Lynch (Northwest High School)
Ion Channels in Mesangial Cells: Function, Malfunction, or Fiction
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Ion Channels in Mesangial Cells: Function, Malfunction, or Fiction

Ion channels in glomerular mesangial cells from humans, rats, and mice have ... (more)

Ion channels in glomerular mesangial cells from humans, rats, and mice have been studied by electrophysiological, molecular, and gene-knockout methods. Two channels, a large, Ca2+-activated K+ channel (BK) and a store-operated Ca2+ channel (SOCC), can be defined with respect to molecular structure and function. Human BK, comprised of a pore-forming {alpha}-subunit and an accessory 퀌ô1-subunit, operate as Ca2+-sensing feedback modulators of contractile tone. SOCC have also been characterized in a mouse cell line; they are comprised of molecules belonging to the transient receptor potential subfamily. (less)

Subject:
Chemistry
Life Science
Physics
Social Sciences
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
MD/PhD Rong Ma (University of North Texas Health Science Center Department of Integrative Physiology)
PhD Jennifer L. Pluznick (University of Nebraska Medical Center Department of Cellular and Integrative Physiology)
Steven C. Sansom (University of Nebraska Medical Center Department of Cellular and Integrative Physiology)
2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni ... (more)

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni smelborp gnivlos rof seuqinhcet gnipoleved no si sisahpmE .scipot decnavda detceles dna scihparg retupmoc ,gnihcraes dna gnitros ,serutcurts atad ,sdohtem laciremun ,secafretni resu lacihparg ,stpecnoc gnimmargorp revoc smelborp gnimmargorp ylkeeW .esruoc eht fo sucof eht si tnempoleved dna ngised erawtfos detneiro-tcejbO .snoitacilppa cifitneics dna gnireenigne rof sdohtem lanoitatupmoc dna tnempoleved erawtfos latnemadnuf stneserp esruoc sihT (less)