This course highlights the interplay between cellular and molecular storage mechanisms and …
This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function. Class sessions include lectures and discussion of papers.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Along with preventing pain, one function of anesthesia is to keep a person from remembering unpleasant experiences. And yet, after surgery, a very small number of patients report distressing events, which can have long-term effects, including PTSD. Anesthesia usually ensures patients lack explicit memory, but implicit memories can still form. Previous studies have suggested that implicit memory formation can occur under sedation, via circuits in the amygdala. To investigate this phenomenon, researchers in Israel conducted experiments on monkeys undergoing anesthesia using two different drugs: ketamine, an NMDA receptor antagonist; and midazolam, a GABA coagonist. The team made single-cell neuron recordings on sedated animals while the animals underwent classical conditioning using tones and an aversive odor. Specifically, the monkeys were conditioned to take a deeper breath after hearing a tone, in anticipation of a noxious odor that would make them inhale less deeply..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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