Keywords: Neuromuscular Junction (5)

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An Emerging Picture of Synapse Formation: A Balance of Two Opposing Pathways
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An Emerging Picture of Synapse Formation: A Balance of Two Opposing Pathways

The neuromuscular junction (NMJ) is a well-studied chemical synapse and has served ... (more)

The neuromuscular junction (NMJ) is a well-studied chemical synapse and has served as a tractable model system to clarify how synapse formation occurs. Proteins on both the presynaptic and postsynaptic sides collaborate to induce the high-density accumulation of acetylcholine receptors (AChRs) at the NMJ. Two opposing pathways work in this process: A dispersing pathway works through acetylcholine and the AChR, and a clustering pathway works through agrin and the transmembrane tyrosine kinase MuSK. The molecular mechanisms underlying these two signaling cascades are beginning to be understood. (less)

Subject:
Life Science
Material Type:
Activities and Labs
Data
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Fumihito Ono (National Institute on Alcohol Abuse and Alcoholism;Laboratory of Molecular Physiology REV)
Myasthenia Gravis (Spanish)
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Myasthenia Gravis (Spanish)

This patient education program discusses myasthenia gravis and how it can be ... (more)

This patient education program discusses myasthenia gravis and how it can be treated. The causes, symptoms, and diagnosis are also reviewed. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. (less)

Subject:
Science and Technology
Material Type:
Audio Lectures
Provider:
National Library of Medicine
Provider Set:
H.E.A.L.
Probabilistic Reasoning in Data Analysis
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Probabilistic Reasoning in Data Analysis

This Teaching Resource provides lecture notes, slides, and a student assignment for ... (more)

This Teaching Resource provides lecture notes, slides, and a student assignment for a lecture on probabilistic reasoning in the analysis of biological data. General probabilistic frameworks are introduced, and a number of standard probability distributions are described using simple intuitive ideas. Particular attention is focused on random arrivals that are independent of prior history (Markovian events), with an emphasis on waiting times, Poisson processes, and Poisson probability distributions. The use of these various probability distributions is applied to biomedical problems, including several classic experimental studies. (less)

Subject:
Mathematics
Computing and Information
Engineering
Life Science
Material Type:
Activities and Labs
Assessments
Images and Illustrations
Instructional Material
Lecture Notes
Lesson Plans
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Lawrence Sirovich (New York;Mount Sinai School of Medicine REV)
The Sherlock Holmes Lab: Investigations in Neurophysiology
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The Sherlock Holmes Lab: Investigations in Neurophysiology

This Teaching Resource describes a research project that can be used in ... (more)

This Teaching Resource describes a research project that can be used in an advanced undergraduate course in neurobiology that covers basic electrophysiology and synaptic transmission. A thought experiment is provided that can be used to assess student understanding of (i) the scientific method, (ii) the process whereby nerve stimulation leads to muscle contraction, and (iii) the use of pharmacological agents to analyze a physiological system. (less)

Subject:
Life Science
Material Type:
Activities and Labs
Assessments
Instructional Material
Lesson Plans
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Elizabeth M. Adler (American Association for the Advancement of Science;Associate Editor of Science's STKE REV)
Paul J. Schwartz (University of Medicine and Dentistry of New Jersey;Department of Neurological Surgery REV)
A Speculative Model of AChR Gating at the Frog Neuromuscular Junction
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A Speculative Model of AChR Gating at the Frog Neuromuscular Junction

The animation depicts a speculative model of nicotinic acetylcholine receptor (AChR) gating ... (more)

The animation depicts a speculative model of nicotinic acetylcholine receptor (AChR) gating at the frog neuromuscular junction. Following a nerve impulse, the neurotransmitter acetylcholine (ACh) is released from synaptic vesicles docked at the active zone of the presynaptic nerve terminal. ACh diffuses across the synaptic cleft to bind to AChRs, ligand-gated channels found at the lips of the postjunctional folds of the muscle, initiating gating, a conformational change that allows ions to flow through the channel and thereby elicit an electrical response in the muscle (the end-plate potential). In the AChR, gating involves a series of small conformational changes that propagate throughout the channel as it moves from "closed" to "open," rather than a synchronous switch in protein configuration. [Resource Details] (less)

Subject:
Life Science
Material Type:
Images and Illustrations
Instructional Material
Readings
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Anthony Auerbach (State University of New York at Buffalo;Center for Single Molecule Biophysics REV)
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2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni ... (more)

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