Keywords: Molecular Biology (352)

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Control of Gene Expression
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Control of Gene Expression

Examples of regulation at each of the steps are known, although for ... (more)

Examples of regulation at each of the steps are known, although for most genes the main site of control is step 1: transcription of a DNA sequence into RNA. (less)

Subject:
Mathematics
Life Science
Education
Material Type:
Images and Illustrations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Alexander Johnson
Bruce Alberts
Dennis Bray
Garland Publishing REV
Julian Lewis
Keith Roberts
Martin Raff
Peter Walter
Control of Gene Expression
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Control of Gene Expression

Examples of regulation at each of the steps are known, although for ... (more)

Examples of regulation at each of the steps are known, although for most genes the main site of control is step 1: transcription of a DNA sequence into RNA. (less)

Subject:
Mathematics
Life Science
Education
Material Type:
Images and Illustrations
Provider:
National Health Museum
Provider Set:
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Alexander Johnson
Bruce Alberts
Dennis Bray
Garland Publishing
Julian Lewis
Keith Roberts
Martin Raff
Peter Walter
Control of the Human B-Globin Gene
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Control of the Human B-Globin Gene

The diagram shows some of the gene regulatory proteins thought to control ... (more)

The diagram shows some of the gene regulatory proteins thought to control expression of this gene during red blood cell development. Some of the gene regulatory proteins shown, such as CP1, are found in many types of cells, while others, such as GATA-1, are present in only a few types of cells, including red blood cell precursors, and are therefore thought to contribute to the cell-type specificity of beta-globin gene expression. As indicated by the bidirectional arrows, several of the binding sites for GATA-1 overlap those of other gene regulatory proteins; it is thought that occupancy of these sites by GATA-1 excludes binding of other proteins. (Adapted from B. Emerson, In Gene Expression: General and Cell-Type Specific (M. Karin, ed.), pp. 116-161. Boston: Birkhauser, 1993.) (less)

Subject:
Mathematics
Life Science
Education
Material Type:
Images and Illustrations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Alexander Johnson
Bruce Alberts
Dennis Bray
Garland Publishing REV
Julian Lewis
Keith Roberts
Martin Raff
Peter Walter
Cooking Up a Molecular Ruler
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Cooking Up a Molecular Ruler

The reviewed student article explains how molecular rulers can measure: bends in ... (more)

The reviewed student article explains how molecular rulers can measure: bends in DNA, how proteins interact with DNA, nano-scale structures, and growth of genetic structures. (less)

Subject:
Life Science
Technology
Education
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Jayanta Fowler Mohanty (Cumberland High School in Cumberland, Rhode Island;)
Cracking the Genetic Code
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Cracking the Genetic Code

This lesson will help students understand what the knowledge of DNA can ... (more)

This lesson will help students understand what the knowledge of DNA can tell us about ourselves and other organisms and species. Students will also learn about the systematic study of the human genome. (less)

Subject:
Life Science
Education
Material Type:
Instructional Material
Lecture Notes
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Science Netlinks;
Creating Embryonic Stem Cell Lines
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Creating Embryonic Stem Cell Lines

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can ... (more)

The inner cell mass (ICM) cells of blastocyst-stage early human embryos can be removed and cultured. These cells can be grown in the lab indefinitely. Various growth factors cause these cells to develop into a variety of differentiated cells, such as muscle or nerve cells. (less)

Subject:
Science and Technology
Material Type:
Images and Illustrations
Readings
Simulations
Video Lectures
Provider:
Howard Hughes Medical Institute
Provider Set:
Howard Hughes Medical Institute
Crime Scene Genetics: Transforming Forensic Science through Molecular Technologies
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Crime Scene Genetics: Transforming Forensic Science through Molecular Technologies

Advances in DNA (deoxyribonucleic acid) technology over the past 25 years have ... (more)

Advances in DNA (deoxyribonucleic acid) technology over the past 25 years have led to spectacularly precise forensic identification techniques, although some applications have also unleashed controversies regarding genetic privacy. Current molecular forensic work is pushing these technologies even further by analyzing extremely damaged DNA and by introducing RNA (ribonucleic acid) techniques to forensics. (less)

Subject:
Life Science
Education
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Melissa Lee Phillips (Freelance Science Writer;)
Criminalistics in the Classroom
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Criminalistics in the Classroom

Crimes are written in the first semester by the upperclass students. Creative ... (more)

Crimes are written in the first semester by the upperclass students. Creative writing and good detective skills are combined in creating such past fictitious, nonviolent, crimes as "The Missing Snow Penguin," "Who Stole the Altar Wine" and "Vicious Valedictorian." Evidence was then collected including trace evidence such as hair, dirt and fibers, fingerprints, objects of clothing, pseudoblood samples, tool marks and impressions and handwriting samples. These objects were stored along with a preliminary police report in an Evidence Box. The suspected criminals in these cases are usually the faculty who generously allow themselves to be mug shot, fingerprinted and described freely as intellectual criminals. During the second semester underclass students solve these crimes motivated by the sheer sense of discovery. They are required to research tools and techniques of the criminalist and perform laboratory analyses to pinpoint the perpetrators. (less)

Subject:
Chemistry
Life Science
Education
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Carolyn Rost (Mother of Mercy High School REV)
Permissions Manager (Access Excellence @ the National Health Museum REV)
Cytoplasmic Factors
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Cytoplasmic Factors

Cytoplasmic factors play a significant part in determining how a cell develops. ... (more)

Cytoplasmic factors play a significant part in determining how a cell develops. This segment discusses their importance in turning the appropriate genes on and off for proper development. (less)

Subject:
Science and Technology
Material Type:
Images and Illustrations
Readings
Simulations
Video Lectures
Provider:
Howard Hughes Medical Institute
Provider Set:
Howard Hughes Medical Institute
DNA Biotechnology
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DNA Biotechnology

This series involves a simulation of restriction enzyme activity and gel electrophoresis ... (more)

This series involves a simulation of restriction enzyme activity and gel electrophoresis and two DNA labs from Carolina Biological. (less)

Subject:
Life Science
Technology
Education
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Peggy Campbell (Melbourne High School REV)
Permissions Coordinator (Access Excellence @ the National Health Museum REV)
DNA Chips
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DNA Chips

In this lesson from Science NetLinks, students will conduct activities from a ... (more)

In this lesson from Science NetLinks, students will conduct activities from a module called "DNA Chips: A Genetics Lab in the Palm of Your Hand." This module is part of the National Institutes of Health Snapshots series, which focuses on a single area of biomedical research to help students understand how science, people, ethics, and history all fit together. The module for this lesson is about the DNA microarray, also known as a DNA chip. (less)

Subject:
Life Science
Education
Material Type:
Instructional Material
Lesson Plans
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Science Netlinks;
DNA Detectives
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DNA Detectives

Many of the revolutionary changes that have occurred in biology since 1970 ... (more)

Many of the revolutionary changes that have occurred in biology since 1970 can be attributed directly to the ability to manipulate DNA in defined ways. The principal tools for this recombinant DNA technology are enzymes that can "cut and "paste" DNA. Restriction enzymes are the "chemical scissors" of the molecular biologist; these enzymes cut DNA at specific nucleotide sequences. A sample of someone's DNA, incubated with restriction enzymes, is reduced to millions of DNA fragments of varying sizes. A DNA sample from a different person would have a different nucleotide sequence and would thus be enzymatically "chopped up" into a very different collection of fragments. We have been asked to apply DNA fingerprinting to determine which suspect should be charged with a crime perpetrated in our city. (less)

Subject:
Life Science
Technology
Education
Material Type:
Activities and Labs
Assessments
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Permissions Manger (Access Excellence @ the National Health Museum REV)
Suzanne Black (Inglemoor High School REV)
DNA Dry Lab
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DNA Dry Lab

This paper, pencil and scissors lab illustrates how the order of nucleotides ... (more)

This paper, pencil and scissors lab illustrates how the order of nucleotides in DNA determines the order of amino acids in proteins. It reinforces the concept that any change in the order of nucleotides can change the order of amino acids in proteins. Questions allow students to work through excercise at their own pace without missing key points. (less)

Subject:
Life Science
Education
Material Type:
Activities and Labs
Instructional Material
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Permissions Manager (Access Excellence @ the National Health Museum REV)
Susan Offner (Milton High School REV)
DNA Isolation from Onion
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DNA Isolation from Onion

Many students find studying DNA difficult because it is so small that ... (more)

Many students find studying DNA difficult because it is so small that the concepts are quite abstract. This lab enables students to work with DNA concretely by easily isolating chromosomal DNA using the same basic tools and methods that scientists use. The lab is a good introduction to using pipets and to using the metric system. If the chemistry of the solutions is taught it is also a great practical application. (less)

Subject:
Life Science
Education
Material Type:
Activities and Labs
Instructional Material
Teaching and Learning Strategies
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
Author:
Access Excellence @ the National Health Museum REV
Kate Dollard (Cambridge Rindge and Latin REV)
DNA Jewelry Models
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DNA Jewelry Models

Making DNA Jewelry Models is a portion of a unit on molecular ... (more)

Making DNA Jewelry Models is a portion of a unit on molecular genetics. Using the directions for this hands-on activity/lab helps students construct a model of DNA to learn DNA structure and decode it to better understand protein synthesis. They also have an actual badge of their DNA literacy to wear or use. Whether a key ring, earrings, bracelet, or necklace, students from fourth grade through adult can do and enjoy this activity. (Even visually impaired students made a model using larger beads.) (less)

Subject:
Chemistry
Life Science
Social Sciences
Education
Material Type:
Activities and Labs
Data
Instructional Material
Lesson Plans
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
National Health Museum
Science and Math Informal Learning Educators (SMILE)
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Access Excellence @ The National Health Museum: The Site for Health and Bioscience Teachers and Learners
SMILE Pathway: Science and Math Activities in One Search
Author:
Access Excellence @ the National Health Museum REV
Catherine Ross
Catherine Sheils Ross (Berkley High School (retired-6/98) REV)
National Health Museum
Permissions Manager (Access Excellence @ the National Health Museum REV)
DNA Microarrays: Background, Interactive Databases, and Hands-on Data Analysis
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DNA Microarrays: Background, Interactive Databases, and Hands-on Data Analysis

DNA microarrays are influencing many areas of biology. DNA microarrays allow investigators ... (more)

DNA microarrays are influencing many areas of biology. DNA microarrays allow investigators to measure simultaneously the activity of every gene in a genome. This paper provides the reader with background information, a set of interactive questions, and most importantly, free software (MAGIC Tool) for use in the undergraduate curriculum. MAGIC Tool (www.bio.davidson.edu/MAGIC) resources allow the user to understand how DNA microarray data are analyzed by providing raw data, instructions, mathematical supplements, and free software that works on all computer platforms. MAGIC Tool facilitates the incorporation of microarrays into any upper level biology course. (less)

Subject:
Science and Technology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Davidson College
Provider Set:
Association for Biology Laboratory Education (ABLE)
Author:
A. Malcolm Campbell
Laurie Heyer
DNA Profiling by Mutliplex PCR Amplification and Genotype Determination by Reverse Dot-Blot Hybridization to Sequence-Specific Oligonucleotide Probes
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DNA Profiling by Mutliplex PCR Amplification and Genotype Determination by Reverse Dot-Blot Hybridization to Sequence-Specific Oligonucleotide Probes

Human DNA profiling has applications in paternity testing and forensics. This exercise ... (more)

Human DNA profiling has applications in paternity testing and forensics. This exercise provides students the opportunity to gain first-hand experience with procedures that are currently used to extract DNA from their own cells, quantify the DNA in the extract, perform a multiplex PCR amplification of several loci used in forensic analysis, and determine their own genotype at those loci. In addition, methods for analyzing results relative to existing population databases will be presented. The exercise is normally presented in the context of a laboratory course in Forensic DNA Analysis that presents students with a variety of techniques that have been and/or continue to be employed in forensic laboratories. (less)

Subject:
Science and Technology
Material Type:
Activities and Labs
Lesson Plans
Provider:
Kennesaw State University
Provider Set:
Association for Biology Laboratory Education (ABLE)
Author:
Ralph Rascati
DNA Sequencing Used to Illustrate Mutations and Evolution
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DNA Sequencing Used to Illustrate Mutations and Evolution

This workshop, which is half wet lab and half Internet lab, uses ... (more)

This workshop, which is half wet lab and half Internet lab, uses DNA sequences to examine the relatedness of different species. DNA from several insect and/or fish species are compared. This chapter includes instructions for extracting DNA from gels and making PCR products. We prepare PCR products to send to a computerized automated sequencing facility. (No radioisotopes are used in this sequencing!) We recover sequence from the facility over the Web as four-color graphics on a computer screen and as text. We make pair-wise DNA sequence comparisons between species with BLAST2 and multi-species comparisons with MultAlin. We see substitutions, insertions, and deletions. Then we make a distance-based evolutionary tree with GeneBee. (less)

Subject:
Science and Technology
Material Type:
Activities and Labs
Lesson Plans
Provider:
St. Francis College
University of Utah
Provider Set:
Association for Biology Laboratory Education (ABLE)
Association for Biology Laboratory Education (ABLE)
Author:
Kathleen A. Nolan
Russell LeMon
Theodore Gurney
DNA from the Beginning
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DNA from the Beginning

DNA from the Beginning is organized around key concepts. The science behind ... (more)

DNA from the Beginning is organized around key concepts. The science behind each concept is explained by: animations, image galleries, video interviews, problems, biographies, and links. (less)

Subject:
Mathematics
Life Science
Education
Material Type:
Images and Illustrations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Cold Spring Harbor Laboratory (Cold Spring Harbor Laboratory;)