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ADAM17 contributes to heart failure after heart attack by promoting loss of cardioprotective ACE2
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Myocardial infarction (MI), or heart attack, can cause long-term damage that leads to heart failure. To treat this type of heart failure, it’s critical to heal the pathological structural changes in the heart and preserve cardiac function. A recent study investigated potential treatment targets by exploring the role of the enzyme ADAM17, whose levels are increased during MI. In a group of 152 patients with MI, high ADAM17 levels were associated with a greater incidence of subsequent heart failure, as well as poorer heart function and higher mortality, suggesting a negative role of ADAM17. In mice with MI, elevated ADAM17 levels were linked to heart damage, but blocking ADAM17 activity limited the cardiac damage and remodeling after MI. Experiments in cultured heart cells revealed that ADAM17 exerted its harmful effects by promoting loss of the cardioprotective enzyme ACE2 and that the activation of ADAM17 depended on modification of a specific site in the protein p38 MAPK..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/17/2023
Child Welfare Practice Guides - Northern California Training Academy
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CC BY-NC-ND
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This resource provides access to the Northern California Training Academy's extensive list of published guides, tips and tools for child welfare practice improvement.

Subject:
Career and Technical Education
Education
Social Science
Material Type:
Interactive
Primary Source
Reading
Date Added:
05/12/2016
D3: DYNAMIC DETROIT DATA@BUNCHE ACADEMY
Conditional Remix & Share Permitted
CC BY-NC-SA
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D3: DYNAMIC DETROIT DATA@ BUNCHE ACADEMY IS A RESOURCE FOR STUDENTS, PARENTS AND TEACHERS TO USE TO FIND CURRICULUM RELATED WEBSITES. THIS IS A USEFUL ONE STOP LOCATION TO START YOUR SEARCH TO RELATED AGE APPROPRIATE CONTENT MATERIAL FOR STUDENT WORK.

Subject:
Arts and Humanities
Mathematics
Social Science
Material Type:
Activity/Lab
Diagram/Illustration
Homework/Assignment
Lecture Notes
Teaching/Learning Strategy
Date Added:
10/09/2012
Information on Myocardial Infarction
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CC BY-NC
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Outline of heart    https://en.wikipedia.org/wiki/HeartDefinition of MI  https://www.merriam-webster.com/dictionary/heart%20attackRisk factors of MIManagement of MI http://emedicine.medscape.com/article/155919-treatmentsimulation of CPRVideo on MI 

Subject:
Health, Medicine and Nursing
Material Type:
Module
Author:
shobha gaikwad
Date Added:
08/09/2017
The roles of neutrophil granules in heart attack pathology
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Myocardial infarction (MI), also known as a heart attack, is a common but serious cardiac emergency. The severity and mortality of MI are related to overactivation of immune cells called neutrophils. Specifically, excessive activation of a process called neutrophil degranulation appears to impair MI recovery. During degranulation, molecules that can help fight pathogens and repair tissue damage are released from cytoplasmic granules. This is normally beneficial, but too much degranulation can aggravate MI-related injury. Four main types of granules are released: primary/azurophilic, secondary/specific, tertiary/gelatinase, and secretory granules. These granule types are synthesized and released at different times and contain different mixtures of molecules. For example, primary granules contain the enzyme MPO, excess levels of which can impair ventricular healing and function after MI, while secondary granules contain NGAL, which can increase the risk of plaque formation and promote inflammation and fibrosis..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/18/2022