Updating search results...

Search Resources

2 Results

View
Selected filters:
  • impedance
Functional test reveals patients who may benefit from c-Met+pan-HER breast cancer therapy
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Coordinated signaling between HER-family receptors and c-Met has been demonstrated to drive breast cancer in some patients. Although combination therapies targeting HER and c-Met can be very effective in some of these patients, no clinical data has supported an approval for this drug combination in breast cancer. In a recent study, researchers examined the ability of a new clinical test to identify potentially responsive patients. The test, called the CELsignia Multi-Pathway Signaling Function Test, uses an impedance biosensor loaded with a patient’s live tumor cells to quantify cell signaling responses in real time. Using this test, the researchers identified patients whose HER2-negative breast tumors had hyperactive coordinated HER1, HER2, HER3/4, and c-Met signaling, despite having normal expression levels of these receptors on their tumor cells. These results indicated that the identified patients might be responsive to HER-/c-Met-targeting combination therapy..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/17/2022
Systems and Controls
Conditional Remix & Share Permitted
CC BY-NC-SA
Rating
0.0 stars

This course provides an introduction to linear systems, transfer functions, and Laplace transforms. It covers stability and feedback, and provides basic design tools for specifications of transient response. It also briefly covers frequency-domain techniques.

Subject:
Applied Science
Engineering
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Barbastathis, George
Date Added:
02/01/2013