Keywords: Degradation (16)

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Blood Clots, Polymers and Strokes
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Blood Clots, Polymers and Strokes

Students are introduced to the circulatory system with an emphasis on the ... (more)

Students are introduced to the circulatory system with an emphasis on the blood clotting process, including coagulation and the formation and degradation of polymers through their underlying atomic properties. They learn about the medical emergency of strokes—the loss of brain function commonly due to blood clots— including various causes and the different effects depending on the brain location, as well as blood clot removal devices designed by biomedical engineers. (less)

Subject:
Chemistry
Ecology
Engineering
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Instructional Material
Lesson Plans
Provider:
TeachEngineering
Author:
Azim Laiwalla, Ann McCabe, Carleigh Samson, Victoria Lanaghan
Science and Engineering of the Environment of Los Angeles (SEE-LA) GK-12 Program,
TeachEngineering.org
CELL BIOLOGY: Smurfing at the Leading Edge
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CELL BIOLOGY: Smurfing at the Leading Edge

Access to the article is free, however registration and sign-in are required. ... (more)

Access to the article is free, however registration and sign-in are required. Cell biologists are only now beginning to unravel how cells maintain their polarity and how this polarity contributes to cell migration. In their Perspective, Jaffe and Hall discuss new research (Wang et al.) describing how ubiquitination and degradation of Rho GTPase (which is an important regulator of the actin cytoskeleton) results in spatial restriction of Rho at the rear of the cell, an essential step in cellular migration. (less)

Subject:
Ecology
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Alan Hall (University College London;MRC Laboratory for Molecular Cell Biology and Cell Biology Unit)
Aron B. Jaffe (University College London;MRC Laboratory for Molecular Cell Biology and Cell Biology Unit)
Degradation of primary wall of vessenl member is almost complete.
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Degradation of primary wall of vessenl member is almost complete.

Degradation of primary wall of vessenl member is almost complete. Primary wall ... (more)

Degradation of primary wall of vessenl member is almost complete. Primary wall of other cell is partly hydrolyzed between the coils of the helix. Older helix subjected to greater amount of stretching. (less)

Subject:
Life Science
Education
Material Type:
Images and Illustrations
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Jennifer Thorsch
Katherine Esau
A Degrading Experience
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A Degrading Experience

In this activity, learners perform an experiment to learn about how different ... (more)

In this activity, learners perform an experiment to learn about how different types of marine debris degrade and how weather and sunlight affect the rate of degradation. Learners discover that debris made from natural materials, while biodegradable, can still be considered pollutants and can still harm the marine environment. (less)

Subject:
Mathematics
Chemistry
Ecology
Engineering
Forestry and Agriculture
Geoscience
Life Science
Physics
Space Science
Technology
Social Sciences
Education
Material Type:
Activities and Labs
Instructional Material
Lesson Plans
Provider:
Science and Math Informal Learning Educators (SMILE)
Provider Set:
SMILE Pathway: Science and Math Activities in One Search
Author:
Katie Reigster
National Oceanic and Atmospheric Administration
NOAA
Seba Sheavly
The Great Pacific Garbage Patch
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The Great Pacific Garbage Patch

The Great Pacific Garbage Patch (GPGP) is an intriguing and publicized environmental ... (more)

The Great Pacific Garbage Patch (GPGP) is an intriguing and publicized environmental problem. This swirling soup of trash up to 10 meters deep and just below the water surface is composed mainly of non-degradable plastics. These plastic materials trap aquatic life and poison them by physical blockage or as carriers of toxic pollutants. The problem relates to materials science and the advent of plastics in modern life, an example of the unintended consequences of technology. Through exploring this complex issue, students gain insight into aspects of chemistry, oceanography, fluids, environmental science, life science and even international policy. As part of the GIS unit, the topic is a source of content for students to create interesting maps communicating something that they will likely begin to care about as they learn more. (less)

Subject:
Chemistry
Computing and Information
Ecology
Engineering
Forestry and Agriculture
Geoscience
Life Science
Physics
Material Type:
Instructional Material
Lesson Plans
Provider:
TeachEngineering
Author:
Andrey Koptelov
Nathan Howell
National Science Foundation GK-12 and Research Experience for Teachers (RET) Programs,
TeachEngineering.org
Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance, Spring 2004
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Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance, Spring 2004

This course is an advanced undergraduate seminar based upon discussions and critical ... (more)

This course is an advanced undergraduate seminar based upon discussions and critical analysis of primary literature in the field of immunology. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease specific immune evasion and the mechanisms used by pathogens to prevail over their host's immune systems are discussed. What these host-pathogen interactions reveal about the normal function of the immune system and about basic cell biological processes, such as protein maturation and degradation, are also considered. (less)

Subject:
Science and Technology
Material Type:
Full Course
Homework and Assignments
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Halme, Dina Gould
Let the Blood Flow
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Let the Blood Flow

Students work as biomedical engineers to find liquid solutions that can clear ... (more)

Students work as biomedical engineers to find liquid solutions that can clear away polyvinyl acetate polymer "blood clots" in model arteries (made of clear, flexible tubing). Teams create samples of the "blood clot" polymer with different concentrations to discover the concentration of the model clot and then test a variety of liquids to determine which most effectively breaks down the model blood clot. Students learn the importance of the testing phase in the engineering design process, because they are only given one chance to present the team's solution and apply it to the model blood clot. (less)

Subject:
Chemistry
Ecology
Engineering
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Instructional Material
Provider:
TeachEngineering
Author:
Azim Laiwalla, Ann McCabe, Carleigh Samson
Science and Engineering of the Environment of Los Angeles (SEE-LA) GK-12 Program,
TeachEngineering.org
Marine Organic Geochemistry, Spring 2005
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Marine Organic Geochemistry, Spring 2005

Provides an understanding of the distribution of organic carbon (OC) in marine ... (more)

Provides an understanding of the distribution of organic carbon (OC) in marine sediments from a global and molecular-level perspective. Surveys the mineralization and preservation of OC in the water column and within anoxic and oxic marine sediments. Topics include: OC composition, reactivity and budgets within, and fluxes through, major reservoirs; microbial recycling pathways for OC; models for OC degradation and preservation; role of anoxia in OC burial; relationships between dissolved and particulate (sinking and suspended) OC; methods for characterization of sedimentary organic matter; application of biological markers as tools in oceanography. Both structural and isotopic aspects are covered. (less)

Subject:
Science and Technology
Material Type:
Activities and Labs
Full Course
Lecture Notes
Syllabi
Provider:
M.I.T.
Provider Set:
MIT OpenCourseWare
Author:
Eglinton, Timothy
A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain
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A New Gun in Town: The U Box Is a Ubiquitin Ligase Domain

Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating ... (more)

Ubiquitin ligases determine protein stability in a highly regulated manner by coordinating the addition of polyubiquitin chains to proteins that are then targeted to the proteasome for degradation. Ubiquitin ligases have generally been separated into two groups--those containing HECT domains and those with RING finger domains. Recently, a third group of ubiquitin ligases has emerged: those containing a U-box domain. Patterson discusses what is known about the few U-box-containing proteins that have been characterized, although the general properties of U-box proteins that distinguish them from other ubiquitin ligases are still a matter of speculation. (less)

Subject:
Ecology
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Data
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Cam Patterson (University of North Carolina at Chapel Hill;Carolina Cardiovascular Biology Center and Department of Medicine, Department of Pharmacology, and Department of Cell and Developmental Biology REV)
Parkinson's Disease: To Live or Die by Autophagy
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Parkinson's Disease: To Live or Die by Autophagy

The identification of the molecular mechanisms underlying neuronal survival continues to be ... (more)

The identification of the molecular mechanisms underlying neuronal survival continues to be the subject of intensive research efforts as the incidence of age-related neurodegenerative diseases rises. Amid a complex mélange of environmental and genetic factors that contribute to disease manifestation, much effort has been dedicated to understanding the underlying signaling mechanisms that regulate neuronal survival. A recent study by Yang et al. sheds new light on an intracellular quality-control system that regulates the constitutive abundance of a neuronal survival factor through chaperone-mediated autophagy and links the deregulation of this pathway to Parkinson’s disease. Although the primary function of autophagy in most cell types has commonly been thought to be an adaptive response to starvation, it has been proposed that proper functioning of this system is essential for neuronal survival and that its deregulation leads to neurodegeneration. (less)

Subject:
Ecology
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Images and Illustrations
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
David S. Park (University of Ottawa;Department of Cellular and Molecular Medicine REV)
Isabella Irrcher (University of Ottawa;Department of Cellular and Molecular Medicine REV)
Preservation of ancient DNA, Svante PaaboSite: DNA Interactive (www.dnai.org)
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Preservation of ancient DNA, Svante PaaboSite: DNA Interactive (www.dnai.org)

Interviewee: Svante Paabo DNAi Location:Applications>Human origins>comparisons>DNA Evolutionary geneticist Svante Paabo talks about ... (more)

Interviewee: Svante Paabo DNAi Location:Applications>Human origins>comparisons>DNA Evolutionary geneticist Svante Paabo talks about the environments that will best preserve ancient DNA. (less)

Subject:
Chemistry
Ecology
Forestry and Agriculture
Geoscience
Life Science
Social Sciences
Education
Material Type:
Instructional Material
Video Lectures
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
David Micklos (Cold Spring Harbor Laboratory;DNA Learning Center X-AUDIENCE)
Elof Carlson (SUNY at Stony Brook;Biology Department X-AUDIENCE)
Garland Allen (Washington University at St. Louis;Biology Department X-AUDIENCE)
Jan Witkowski (Cold Spring Harbor Laboratory;Banbury Center X-AUDIENCE)
Paul Lombardo (University of Virginia;Center for Biomedical Ethics X-AUDIENCE)
Steven Selden (University of Maryland;Education Policy and Leadership Department X-AUDIENCE)
Science Signaling Podcast: 7 December 2010
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Science Signaling Podcast: 7 December 2010

This is a conversation with Lan Huang about a Research Article published ... (more)

This is a conversation with Lan Huang about a Research Article published in the 7 December 2010 issue of Science Signaling. Wang and colleagues report that oxidative stress triggers separation of the catalytic and regulatory portions of the yeast proteasome, thus enabling the catalytic core to switch from degrading ubiquitinated proteins to degrading potentially toxic oxidized proteins. This response was also observed in human cells, suggesting that this mechanism for surviving oxidative stress might be conserved throughout eukaryotes. (less)

Subject:
Chemistry
Ecology
Forestry and Agriculture
Geoscience
Life Science
Education
Material Type:
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Annalisa M. VanHook (American Association for the Advancement of Science;Science Signaling REV)
Lan Huang (Irvine;University of California REV)
Two papers entitledSite: DNA Interactive (www.dnai.org)
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Two papers entitledSite: DNA Interactive (www.dnai.org)

Interviewee: Arthur Kornberg

Subject:
Chemistry
Ecology
Forestry and Agriculture
Geoscience
Life Science
Education
Material Type:
Instructional Material
Video Lectures
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
David Micklos (Cold Spring Harbor Laboratory;DNA Learning Center X-AUDIENCE)
Elof Carlson (SUNY at Stony Brook;Biology Department X-AUDIENCE)
Garland Allen (Washington University at St. Louis;Biology Department X-AUDIENCE)
Jan Witkowski (Cold Spring Harbor Laboratory;Banbury Center X-AUDIENCE)
Paul Lombardo (University of Virginia;Center for Biomedical Ethics X-AUDIENCE)
Steven Selden (University of Maryland;Education Policy and Leadership Department X-AUDIENCE)
When the Beginning Marks the End
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When the Beginning Marks the End

Acetylation of the amino terminus (Nt-acteylation) of a protein is one of ... (more)

Acetylation of the amino terminus (Nt-acteylation) of a protein is one of the most common modifications, occurring in about 50% of yeast proteins and more than 80% of human proteins. This perspective discusses a report by Hwang et al., who demonstrated that acetylation of the amino terminus of a protein can function as a degration signal (degron), revealing an entirely unexpected role of acetylation in protein turnover and possibly homeostasis. (less)

Subject:
Ecology
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Activities and Labs
Instructional Material
Reference
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Axel Mogk (Zentrum f퀌_r Molekulare Biologie der Universit퀌_t Heidelberg (ZMBH);DKFZ-ZMBH Alliance)
Bernd Bukau (Zentrum f퀌_r Molekulare Biologie der Universit퀌_t Heidelberg (ZMBH);DKFZ-ZMBH Alliance)
iBioSeminar: The Life of Eukaryotic mRNA
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iBioSeminar: The Life of Eukaryotic mRNA

The control of mRNA production and function is a key aspect of ... (more)

The control of mRNA production and function is a key aspect of the regulation of gene expression. Eukaryotic cells, the control of mRNA localization, translation and degradation in the cytoplasm allow for the proper regulation of the amount, duration, and location of protein production. The basic mechanisms of these processes are understood and reveal that the mechanisms of localization, translation, and degradation are interconnected. (less)

Subject:
Mathematics
Ecology
Forestry and Agriculture
Geoscience
Life Science
Material Type:
Instructional Material
Lecture Notes
Provider:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Provider Set:
BiosciEdNet (BEN): Digital Library Portal for Teaching and Learning in the Biological Sciences
Author:
Roy Parker (University of Arizona and Howard Hughes Medical Institute;)
2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

2002 llaF ,gnivloS melborP gnireenignE dna sretupmoC ot noitcudortnI

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni ... (more)

.desu si egaugnal gnimmargorp avaJ ehT .gninnalp dna ,tnemeganam ,ecneics ,gnireenigne ni smelborp gnivlos rof seuqinhcet gnipoleved no si sisahpmE .scipot decnavda detceles dna scihparg retupmoc ,gnihcraes dna gnitros ,serutcurts atad ,sdohtem laciremun ,secafretni resu lacihparg ,stpecnoc gnimmargorp revoc smelborp gnimmargorp ylkeeW .esruoc eht fo sucof eht si tnempoleved dna ngised erawtfos detneiro-tcejbO .snoitacilppa cifitneics dna gnireenigne rof sdohtem lanoitatupmoc dna tnempoleved erawtfos latnemadnuf stneserp esruoc sihT (less)