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Collagen formation
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As taught Semesters 1 and 2, 2011

The learning object describes how collagen fibres are assembled in the formation of connective tissue. The learning object is used as part of the level 1 Biological Sciences module delivered by the School of Nursing, Midwifery and Physiotherapy.

Dr Andy Meal, Lecturer in Biological Sciences, School of Nursing, Midwifery and Physiotherapy

Subject:
Life Science
Material Type:
Diagram/Illustration
Lesson
Provider:
University of Nottingham
Author:
Dr Andy Meal
Colleen McCants
Date Added:
03/23/2017
Exploring and avoiding morphine-induced spinal masses
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Harmful masses that accompany regular spinal or intrathecal infusions of opiates for pain management might one day be a concern of the past. Researchers have uncovered the cellular mechanisms behind these lesions, which occur with some opioids but not others. Their findings could help improve spinal pain therapy for patients without compromising their health or quality of life. Intrathecal opioids such as morphine are highly effective for managing pain. Direct access to opioid receptors in the spinal cord has made round-the-clock pain management possible, most notably through the use of so-called “pain pumps”. One concern, however, has been the possible formation of collagen-rich masses around the area of drug delivery. These masses, or granulomas, occur in about 8% of patients receiving spinal morphine infusions and have been linked, ironically, to increased pain and reduced neurological function..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Formation of Cartilage · Science Animation
Unrestricted Use
CC BY
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This animation describes the process of cartilage formation starting with separation from the mesenchymal tissue to the formation of an isogenous cell group via mitosis.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Simulation
Provider:
CUNY
Provider Set:
City College
Author:
Abraham Kierszenbaum
Aleksandr Vinkler
Ching-Jung Chen
Jazmine Rogers
Lena Marvin
Robert Levy
Date Added:
06/16/2022
Living with Your Liver
Read the Fine Print
Educational Use
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Students learn the function of the liver and how biomedical engineers can use liver regeneration to help people. Students test the effects of toxic chemicals on a beef liver by adding hydrogen peroxide to various liver and salt solutions. They observe, record and graph their results.

Subject:
Anatomy/Physiology
Applied Science
Engineering
Life Science
Material Type:
Activity/Lab
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Denise W. Carlson
Malinda Schaefer Zarske
Megan Schroeder
Date Added:
10/14/2015
Methylene blue, a common antioxidant, could reverse signs of aging in human skin
Unrestricted Use
CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Antioxidants – considered by many the superheroes of the dietary world – are reported to do everything from improving heart health to helping fight cancer. They’re also a common anti-aging ingredient in skin care lines. University of Maryland researchers have narrowed down one antioxidant that seems to significantly outperform others in the anti-aging arena: methylene blue – a chemical used in research laboratories across the world. In a recent study published in Scientific Reports, the team showed that applying the molecule to a reconstructed skin model can slow or even reverse several well-known signs of aging, opening the door to new, more effective cosmetic treatments. The team compared the performance of methylene blue against three other popular antioxidants on skin cells collected from healthy young donors, elderly people, and individuals with progeria – a genetic condition that causes accelerated aging..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Biology
Chemistry
Health, Medicine and Nursing
Life Science
Physical Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Molecular, Cellular, and Tissue Biomechanics
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CC BY-NC-SA
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This course develops and applies scaling laws and the methods of continuum and statistical mechanics to biomechanical phenomena over a range of length scales, from molecular to cellular to tissue or organ level.

Subject:
Applied Science
Biology
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Grodzinsky, Alan
Kamm, Roger
Date Added:
02/01/2015
Molecular Structure of Biological Materials (BE.442)
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CC BY-NC-SA
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This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to give guest lectures.

Subject:
Applied Science
Biology
Engineering
Life Science
Physical Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Zhang, Shuguang
Date Added:
09/01/2005
Nanomechanics of Materials and Biomaterials
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CC BY-NC-SA
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This course focuses on the latest scientific developments and discoveries in the field of nanomechanics, the study of forces and motion on extremely tiny (10 m) areas of synthetic and biological materials and structures. At this level, mechanical properties are intimately related to chemistry, physics, and quantum mechanics. Most lectures will consist of a theoretical component that will then be compared to recent experimental data (case studies) in the literature. The course begins with a series of introductory lectures that describes the normal and lateral forces acting at the atomic scale. The following discussions include experimental techniques in high resolution force spectroscopy, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of single macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors.

Subject:
Applied Science
Biology
Chemistry
Engineering
Life Science
Physical Science
Physics
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Ortiz, Christine
Date Added:
02/01/2007
Objective assessment of ACL graft status after ACL reconstruction using T2* MRI
Unrestricted Use
CC BY
Rating
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The timing of return to play is one of the most critical decisions made following ACL reconstruction. Returning too early carries the risk of graft failure, while returning too late could cost patients financial and athletic opportunities. Unfortunately, no universal, objective method exists to determine the best time for athletes to resume full activities. But according to a new study reported in The American Journal of Sports Medicine, such methods could be on the horizon, with the help of MRI technology. One promising marker for estimating the best time for athletes to return to play is ACL graft maturation. That’s the process by which a surgical graft makes the transformation from tendon tissue into a substance similar to a normal ACL. The problem is that this transformation is difficult to track over time. Tissue biopsies are currently the gold standard, but are invasive and, in most cases, impractical to perform..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Anatomy/Physiology
Applied Science
Health, Medicine and Nursing
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/23/2020
Principles and Practice of Tissue Engineering
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CC BY-NC-SA
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The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.
Archived webcast lecture videos for the Fall 2008 version of this class can be found at the HST.535 Fall 2008 website.

Subject:
Applied Science
Biology
Engineering
Life Science
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Cui, Fu-Zhai
Spector, Myron
Date Added:
09/01/2004
Skin and the Effects of Ultraviolet Radiation
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Educational Use
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Towards finding a solution to the unit's Grand Challenge Question about using nanoparticles to detect, treat and protect against skin cancer, students continue the research phase in order to answer the next research questions: What is the structure and function of skin? How does UV radiation affect the chemical reactions that go on within the skin? After seeing an ultraviolet-sensitive bead change color and learning how they work, students learn about skin anatomy and the effects of ultraviolet radiation on human skin, pollution's damaging effect on the ozone layer that can lead to increases in skin cancer, the UV index, types of skin cancer, ABCDEs of mole and lesion evaluation, and the sun protection factor (SPF) rating system for sunscreens. This prepares students to conduct the associated activity, in which they design quality-control experiments to test SPF substances.

Subject:
Applied Science
Engineering
Health, Medicine and Nursing
Material Type:
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Amber Spolarich
Michelle Bell
Date Added:
10/14/2015
Tissue Mechanics
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Educational Use
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Students reflect on their experiences making silly putty (the previous hands-on activity in the unit), especially why changing the borax concentration alters the mechanical properties of silly putty and how this pertains to tissue mechanics. Students learn why engineers must understand tissue mechanics in order to design devices that will be implanted or used inside bodies, to study pathologies of tissues and how this alters tissue function, and to design prosthetics. Finally, students learn about collagen, elastin and proteoglycans and their roles in giving body tissues their unique functions. This prepares them for the culminating design-build-test activity of the unit.

Subject:
Applied Science
Engineering
Material Type:
Lesson Plan
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Brandi N. Briggs
Date Added:
09/18/2014