Updating search results...

Search Resources

6 Results

View
Selected filters:
  • cardiology
Beclin-1 controls caspase-4 inflammasome activation and pyroptosis after myocardial injury
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Reperfusion of heart tissue with blood after interruption of the blood supply (ischemia) often contributes to inflammation and cell death, including a specific form of cell death called pyroptosis, which can be regulated by the protein caspase-4. The protein beclin-1 is involved in an intracellular degradation process called autophagy that can limit cell death. However, whether beclin-1 limits caspase-4-mediated pyroptosis after heart reperfusion injury remains unclear. To find out, a recent study examined the effects of beclin-1 overexpression in mouse hearts and cultured human heart cells subjected to ischemia/reperfusion. Ischemia/reperfusion increased caspase-4 activity and the expression of the pyroptosis protein gasdermin D. In contrast, beclin-1 overexpression decreased caspase-4 activity, gasdermin D expression, and the levels of the inflammation molecule IL-1β..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
03/01/2022
Biomedical Signal and Image Processing
Conditional Remix & Share Permitted
CC BY-NC-SA
Rating
0.0 stars

This course presents the fundamentals of digital signal processing with particular emphasis on problems in biomedical research and clinical medicine. It covers principles and algorithms for processing both deterministic and random signals. Topics include data acquisition, imaging, filtering, coding, feature extraction, and modeling. The focus of the course is a series of labs that provide practical experience in processing physiological data, with examples from cardiology, speech processing, and medical imaging. The labs are done in MATLAB® during weekly lab sessions that take place in an electronic classroom. Lectures cover signal processing topics relevant to the lab exercises, as well as background on the biological signals processed in the labs.

Subject:
Applied Science
Career and Technical Education
Electronic Technology
Engineering
Health, Medicine and Nursing
Material Type:
Full Course
Provider:
MIT
Provider Set:
MIT OpenCourseWare
Author:
Clifford, Gari
Fisher, John
Greenberg, Julie
Wells, William
Date Added:
02/01/2007
Effects of popular heart attack drug get another hard look
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study re-examining the validity of a major drug trial might have doctors rethinking how to treat heart attack survivors. Bolstered by the findings of a landmark clinical trial reported in 2015, the blood thinner ticagrelor has been increasingly prescribed by doctors to reduce the risk of heart attack in people with a history of heart problems. Now, researchers from France say those findings don’t apply to all patients who meet the original study’s criteria. That bias could prove critical for prescribers, who may witness more cases of serious bleeding and death among their patients than previously reported. The 2015 drug study, known as the PEGASUS trial, screened heart attack survivors from around the globe. Those selected for the trial had to be at least 65 years old, or at least 50 with diabetes. Results showed that, when combined with aspirin, ticagrelor significantly decreased the risk of stroke or a second heart attack. It did, however, increase the risk of major bleeding..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
Floppy Heart Valves
Read the Fine Print
Educational Use
Rating
0.0 stars

Students are presented with an engineering challenge that asks them to develop a material and model that can be used to test the properties of aortic valves without using real specimens. Developing material that is similar to human heart valves makes testing easier for biomedical engineers because they can test new devices or ideas on the model valve instead of real heart valves, which can be difficult to obtain for research. To meet the challenge, students are presented with a variety of background information, are asked to research the topic to learn more specific information pertaining to the challenge, and design and build a (prototype) product. After students test their products and make modifications as needed, they convey background and product information in the form of portfolios and presentations to the potential buyer.

Subject:
Applied Science
Engineering
Health, Medicine and Nursing
Material Type:
Full Course
Provider:
TeachEngineering
Provider Set:
TeachEngineering
Author:
Michael Duplessis
Date Added:
10/14/2015
A Narrative Review and Expert Panel Recommendations on Dyslipidaemia Management After Acute Coronary Syndrome
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Dyslipidemia is a major risk factor for cardiovascular disease, especially among patients who have experienced acute coronary syndrome, or ACS. Unfortunately, guidelines for managing dyslipidemia aren’t always followed in practice. In a new study, an expert panel examines barriers to dyslipidemia management faced by patients and physicians outside of Western Europe and North America—and proposes ways of reducing them. Reducing low-density lipoprotein cholesterol, or LDL-C, is the primary target of lipid-modifying therapy for dyslipidemia, as it reduces the risk of cardiovascular disease through proposed mechanisms such as plaque stabilization or reduced inflammation. The American Heart Association and American College of Cardiology recommend at least a 50% reduction in LDL-C, but recommend intensification of therapy if LDL-C values remain at or above 1.8 mmol/L. Meanwhile, the European Society of Cardiology and European Atherosclerosis Society recently lowered their recommended goal to 1..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Biology
Health, Medicine and Nursing
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/30/2020
Role of zinc-mediated CREB pathway activation in PASMC proliferation during PH
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The transcription factor CREB plays an important role in the development of pulmonary hypertension (PH). However, both increased and decreased CREB expression have been proposed to mediate the proliferation of pulmonary artery smooth muscle cells (PASMCs). Additionally, the regulatory signaling of CREB activation in PASMCs proliferation has not been well characterized in PH. Researchers recently used various in vitro techniques to clarify CREB’s role. CRE-containing genes were upregulated in PH PASMCs, and total and phosphorylated CREB protein levels were elevated in PASMCs from rats with monocrotaline (MCT)-induced PH. Prolonged upregulation of serum-induced CREB phosphorylation was also observed in hypoxia-pretreated PASMCs. These results may have been due to activation of multiple protein kinases and downregulation of numerous phosphatases targeting CREB..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/13/2021