This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study shows that abnormal production of nitric oxide in the body leads to the progression of breast cancer in mice. This finding could open the door to new treatments for early-stage breast cancer that stabilize the production of this pivotal molecule. Nearly one-third of newly diagnosed breast cancers in the US are early-stage lesions. Though technically pre-cancerous, about 40% of these lesions could progress to invasive cancers. Researchers don’t yet fully understand what drives these insidious formations. But various studies have reported a common link between cancer risk factors related to lifestyle—such as a high-fat diet, high alcohol consumption, and low physical activity—and abnormal production of nitric oxide. Normally, physiological stress triggers the production of large amounts of nitric oxide. This activates tissue-specific functions of neurons, muscles, immune cells, blood vessels and other specialized cells..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Breast cancer is now the second leading cause of cancer-related deaths in women. However, because of its resistance to many cancer-fighting drugs, only a few treatment options are available. Emphasizing the need to discover and develop new methods for battling this disease. Signal transducer and activator of transcription 3 (STAT3) is known to contribute to breast cancer progression, proliferation, metastasis, and drug resistance. Making STAT3 a promising target for breast cancer therapy. A recent review reports what is currently known about the role of STAT3 pathways in breast cancer. and gives an update on the drugs currently available for targeting STAT3 pathways. New upstream regulators and downstream targets of STAT3 have been discovered and are potential drug targets, and combination therapy targeting mammalian target of rapamycin (mTOR) and STAT3 is a promising treatment option..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"A new study reports the benefits of the traditional Chinese medicine YYFZBJS against colorectal cancer in mice. YYFZBJS is a three-part blend containing Yi-Yi-Ren, or Job’s tears seed, Fu-Zi, or monkshood, and Bai-Jiang-Cao, or patrinia. YYFZBJS has been used for nearly 1000 years to treat gastrointestinal orders. To test its effect against colorectal cancer. researchers delivered YYFZBJS to mice by fecal microbiota transplantation from humans. Mice were fed stool samples from volunteers consuming YYFZBJS or from control donors. Experiments showed that YYFZBJS treatment reduced colon and intestinal tumors. This effect could be due to alterations to the colon microbiome triggered by YYFZBJS. These modifications could regulate the activity of regulatory T cells, which directly affect colorectal cancer cell dynamics. In-depth studies are needed to confirm YYFZBJS’s mechanism of action and its potential to help patients with colorectal cancer..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.