This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

This course covers sensing and measurement for quantitative molecular/cell/tissue analysis, in terms of genetic, biochemical, and biophysical properties. Methods include light and fluorescence microscopies; electro-mechanical probes such as atomic force microscopy, laser and magnetic traps, and MEMS devices; and the application of statistics, probability and noise analysis to experimental data. Enrollment preference is given to juniors and seniors.

This course addresses the challenges of defining a relationship between exposure to environmental chemicals and human disease. Course topics include epidemiological approaches to understanding disease causation; biostatistical methods; evaluation of human exposure to chemicals, and their internal distribution, metabolism, reactions with cellular components, and biological effects; and qualitative and quantitative health risk assessment methods used in the U.S. as bases for regulatory decision-making. Throughout the term, students consider case studies of local and national interest.

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

GEM Vision
GEM has brought together researchers and professionals in major institutions across the globe with distinctly different, but complementary, expertise and facilities to address significant problems at the intersections of select topics of engineering, life sciences, technology, medicine and public health.
GEM creates new models for interactions across scientific disciplinary boundaries whereby problems spanning the range of fundamental science to clinical studies and public health can be addressed on a global scale through strategic international partnerships.
Through initial focus areas in cell and molecular biomechanics, and environmental health, in the context of select human diseases, GEM creates a global forum for the definition and exploration of grand challenges and scientific studies, for the cross-fertilization of ideas among engineers, life scientists and medical professionals, and for the development of novel educational tools.
GEM Activities
GEM enables the brokering of engineers, life scientists and medical professionals with shared facilities and joint students and post-doctoral fellows to tackle major problems in the context of human health and diseases that call for state-of-the-art experimental and computational tools in cell and molecular mechanics, biology and medicine. Broad examples of problems addressed include:

infectious diseases such as malaria,
cancer,
cardiovascular diseases,
biomechanical origins of inflammation.

In each of these areas, the initial emphasis has included (but will not be limited to) molecular, subcellular and cellular mechanics applied to biomedicine, where a single investigator or institution is not likely to have the full spectrum of expertise, infrastructure or resources available to cover fundamental molecular science all the way to clinical studies and societal implications. Currently, twelve institutions in North America, Europe and Asia participate in this effort as Core institutions, focusing on mechanistic studies, as well as novel methods for diagnostics, vaccines or drug development and delivery.
Funds have been raised to provide a structure for coordinated studies from major organizations under the umbrella of GEM. These funds are being used for:

organization of major symposia/conferences specifically targeted at the theme areas of the initiative,
training grants for student fellowships for the partner institutions,
summer schools to develop teaching materials,
the exchange of students and researchers,
operations of a central secretariat for handling the administrative and infrastructure details for such interactions,
maintenance of a web site for dissemination of information.

GEM Online

Students learn about material balances, a fundamental concept of chemical engineering. They use stoichiometry to predict the mass of carbon dioxide that escapes after reacting measured quantities of sodium bicarbonate with dilute acetic acid. Students then produce the reactions of the chemicals in a small reactor made from a plastic water bottle and balloon.

Bioengineering at MIT is represented by the diverse curricula offered by most Departments in the School of Engineering. This course samples the wide variety of bioengineering options for students who plan to major in one of the undergraduate Engineering degree programs. The beginning lectures describe the science basis for bioengineering with particular emphasis on molecular cell biology and systems biology. Bioengineering faculty will then describe the bioengineering options in a particular engineering course as well as the type of research conducted by faculty in the department.

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, rigorous data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on genome engineering, expression engineering, and biomaterial engineering.
This OCW site is based on the source OpenWetWare class Wiki, found at 20.109(F07): Laboratory Fundamentals of Biological Engineering.

This course focuses on the latest scientific developments and discoveries in the field of nanomechanics, the study of forces and motion on extremely tiny (10 m) areas of synthetic and biological materials and structures. At this level, mechanical properties are intimately related to chemistry, physics, and quantum mechanics. Most lectures will consist of a theoretical component that will then be compared to recent experimental data (case studies) in the literature. The course begins with a series of introductory lectures that describes the normal and lateral forces acting at the atomic scale. The following discussions include experimental techniques in high resolution force spectroscopy, atomistic aspects of adhesion, nanoindentation, molecular details of fracture, chemical force microscopy, elasticity of single macromolecular chains, intermolecular interactions in polymers, dynamic force spectroscopy, biomolecular bond strength measurements, and molecular motors.