This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Autoimmune hepatitis (AIH) is a chronic immune-mediated liver disease that’s often treated with the steroid prednisone. Gut microbiome disruption and immune follicular T helper (Tfh) cells play important roles in AIH pathogenesis and progression but how microbes and Tfh cells interact in the context of AIH and prednisone treatment remains unclear. A recent study investigated the effects of both probiotic and prednisone treatment on Tfh cells and AIH indicators. In both human patients and mice, the probiotic Lactobacillus significantly increased the abundance of beneficial gut bacteria and in humans, Lactobacillus enhanced prednisone’s ameliorative effects on clinical AIH indices, such as the serum levels of liver damage–related enzymes. In mice with experimental AIH (EAH), Lactobacillus and prednisone both exerted similar effects, decreasing intestine and liver injury and Lactobacillus again improved prednisone efficacy, reducing the circulating levels of liver damage markers..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Autoimmune disease happens when the body’s immune system reacts to its own cells and tissues. Central to this process are regulatory T cells (Tregs), which control the inflammatory CD4 T cell response. Understanding how to boost Tregs will help researchers develop new therapies for autoimmunity. In a recent study, researchers zeroed in on a broad regulator of cell differentiation, migration, and proliferation – MKL-1. Using molecular techniques, they examined its interaction with STAT5, a transcriptional activator central to Treg development. After overexpressing or silencing MKL-1 and STAT5 in cell lines, they evaluated protein interactions and Treg gene expression. The results showed that MKL-1 acts a coactivator for STAT5b targets in Tregs. MKL-1 was upregulated during Treg differentiation, and overexpressing MKL-1 enhanced the expression of Treg markers. Silencing STAT5b blocked MKL-1 from activating Treg genes, showing its dependence on STAT5b for its function..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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