This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"G protein-coupled receptors (GPCRs) are key proteins that help transmit extracellular signals into cells. Arrestin molecules help regulate GPCR signaling by recognizing and binding to GPCR residues that have been phosphorylated specifically by the kinase GRK. Two models, the barcode model and the flute model, have been proposed to explain this process. In the barcode model, different protein kinases produce different phosphorylation “barcodes” on GPCRs and arrestins “read” the barcodes produced by GRK to produce certain signaling outcomes. In the flute model, different phosphorylation patterns form different sequences of “notes”. These notes can then be “played” in various ways by the different structural features of arrestins, enabling multiple “songs” (outcomes) to be produced from one set of notes..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/18/2022