This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Sometimes viruses release RNA into the host’s cytosol, and detecting that RNA is a critical part of the host’s antiviral immune response. But cells need to have a set of brakes to regulate these responses, otherwise they can trigger harmful overproduction of type I interferon proteins. The kinase MST4 is one part of this ‘braking’ system. Previous work found that MST4 limits damaging inflammatory responses by adding a phosphate group to the adaptor protein TRAF6. But researchers wanted to know how MST4 might regulate type I interferon production. So, in a recent study, they determined that MST4 also competes with another TRAF protein, TRAF3, to bind MAVS. MAVS is a key antiviral signaling protein, and when MST4 binds it instead of TRAF3, type I interferon production is slowed. They also found that MST4 facilitated interactions between MAVS and the ubiquitin ligase Smurf1, which encouraged degradation of MAVS..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 04/14/2023