This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Gallbladder cancer (GBC) is becoming increasingly common, especially in American Indian and Southeast Asian populations. Early GBC can be successfully removed with surgery, but advanced GBC has a poor prognosis . and the existing treatments have many side effects. To explore better therapies, researchers recently investigated the anti-GBC effects of penfluridol, an antipsychotic drug with anticancer activity. In vitro, penfluridol (PF) strongly inhibited the replication and invasion of three GBC cell lines, confirming its anti-GBC potential, but it also dramatically increased glucose consumption via glycolysis, which is a hallmark of cancer. Specifically, penfluridol activated the AMPK/PFKFB3 glycolysis pathway. However, inhibiting glycolysis, particularly the AMPK/PFKFB3 pathway (with Compound C, CC) solved this problem enhancing penfluridol’s GBC-killing effects. The same synergistic effects were observed in mouse tumor models in vivo..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 04/14/2023