Join Stuart Lipton of The Burnham Institute and discover important anti-aging strategies, the latest drugs for degenerative disorders such as AlzheimerŐs disease and the potential use of human stem cells for neurological conditions. (57 minutes)
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Antioxidants – considered by many the superheroes of the dietary world – are reported to do everything from improving heart health to helping fight cancer. They’re also a common anti-aging ingredient in skin care lines. University of Maryland researchers have narrowed down one antioxidant that seems to significantly outperform others in the anti-aging arena: methylene blue – a chemical used in research laboratories across the world. In a recent study published in Scientific Reports, the team showed that applying the molecule to a reconstructed skin model can slow or even reverse several well-known signs of aging, opening the door to new, more effective cosmetic treatments. The team compared the performance of methylene blue against three other popular antioxidants on skin cells collected from healthy young donors, elderly people, and individuals with progeria – a genetic condition that causes accelerated aging..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Hematopoietic stem cells (HSCs) are immature cells that can develop into all types of blood cells, making them critical regulators of blood composition. However, during aging, HSCs undergo a process called senescence, in which their functionality starts to fade, leading to issues like reduced immune cell populations or leukemia. HSC senescence is influenced by various age-related factors, like accumulated DNA damage or epigenetic (non-DNA-altering) changes in gene expression, and it’s regulated by small RNA molecules known as microRNAs (miRNAs). For example, the miR-212/132 cluster binds to the FOXO3 gene to affect HSC life cycles, function, and survival and is upregulated with aging, while miR-125b, which can help HSCs resist stress and cell death, is downregulated in aging HSCs..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Rapamycin is a promising candidate as an anti-aging drug. Normally used to fight cancer, rapamycin has been shown to extend the lifespan of mice. But what about humans? To find out, researchers monitored the effect of rapamycin on test tubes of human coronary artery endothelial cells. These cells are integral to the structure and homeostasis of blood vessels in the heart but tend to harden with age, posing a looming threat to older individuals. Experiments showed that while rapamycin suppressed the expression of certain senescence-related proteins, it actually promoted endothelial cell differentiation into mesenchymal cells through morphological changes by activating autophagy, causing a functional modification. Because heart function is supported by the vascular network, induction of the endothelial–mesenchymal transition can drive the pathogenesis of heart disease..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.