This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Liver cancer is among the most common types of cancer worldwide. Between 2007 and 2017, liver cancer ranked 7th on the list of cancers with the highest global incidence. Through carcinogenesis, cancer cells go through complex and dynamic phenotypical changes -epithelial-to-mesenchymal transition (EMT), or its reverse mesenchymal-to-epithelial transition (MET)- to cope with metastasis rate-limiting steps. Tumor cells gain metastatic properties in EMT, whereas cells acquire tumor forming capabilities in MET. Growing evidence suggests that cells showing both types of properties are most likely to contribute metastatic outgrowth and resistant to therapeutics. Now, a new study has identified a pivotal molecular mechanism that gives rise to this “hybrid epithelial/mesenchymal (E/M)” state. Experiments on human liver cancer cells indicated that the process modulated by lncRNA HOTAIR, a non-coding RNA that contributes to metastasis and poor prognosis in liver cancer..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 11/03/2020