This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Human immunodeficiency virus (HIV) and the malaria-causing parasite Plasmodium infect millions of people around the globe. These two diseases have broad overlap in their endemic regions, and in some areas over a quarter of HIV patients also have malaria. But despite how common coinfection is, researchers know little about how coinfection and order of infection impact patients. So, a team of scientists turned to a Chinese rhesus macaque research model. In this model, instead of HIV, the macaques had the related virus simian immunodeficiency virus (SIV). The scientists found that animals infected with the malaria parasite before SIV produced more of the immune cells that SIV uses to replicate, increasing the viral load and accelerating disease progression. But when the infection order was reversed, a subsequent malaria infection activated virus-specific T cells against SIV. ultimately improving survival in those animals..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by …
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Interactions among probiotics, resident gut microbes and host factors affect probiotic engraftment and the resulting therapeutic effects. These interactions depend on gut-adaptive evolution of the probiotic strains, but the underlying processes—and their differences among host species—are unclear. In addition, the evolutionary effects of probiotics on native gut microbes are not well characterized. A recent genomics study examined the evolution and effects of the probiotic Lactiplantibacillus plantarum HNU082 (Lp082) in the human, mouse, and zebrafish gut. In all three species, Lp082 acquired single-nucleotide mutations. In vitro, the gut-adapted strains exhibited improved fitness related to carbohydrate utilization and acid tolerance and remained genetically stable for three months. In the human and mouse gut, Lp082 engraftment increased the numbers of mutations of the resident gut microbiota (GM) by 10- to 70-fold..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
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