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Extracellular vesicles from tumor endothelial cells promote cancer progression
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Angiogenesis, the process of new blood vessel formation, is a critical step in tumor formation and development. In addition to enabling the growth of individual tumors, angiogenesis helps tumor cells metastasize to distant organs, which makes the factors involved in angiogenesis potential targets for cancer therapies. For example, small enclosed sacs called extracellular vesicles (EVs) that are released from tumor cells can promote angiogenesis. These EVs encapsulate proteins and RNA molecules that can activate nearby endothelial cells in the tumor microenvironment. In turn, the endothelial cells release their own EVs, whose contents may help remodel the extracellular matrix and regulate immunity to facilitate tumor progression. EVs’ ability to deliver materials while evading immune surveillance is especially promising for cancer treatment. Specifically, EVs can be engineered to carry cancer-fighting drugs or small RNA molecules that silence certain genes..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023