3-part lecture series given at Kwame Nkrumah University of Science and Technology about infections with Gram-negative obligate anaerobes
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Penile circumcision dramatically reduces the risk of contracting HIV-1. This protection likely has multiple physical and biological mechanisms, and understanding these mechanisms could lead to non-surgical interventions to reduce HIV-1 transmission. Thus, researchers examined the microbiota and immune milieu before and after elective circumcision in two key areas. The coronal sulcus (CS), which is exposed to the air by foreskin removal and the urethra, which is thought to be the primary site of penile HIV-1 infection in circumcised men. The CS showed a dramatic decrease in pro-inflammatory anaerobic bacteria after circumcision, as well as significantly reduced inflammatory cytokines and chemokines. Circumcision also altered the urethral microbiota. However — in contrast to the CS — there were few changes to the urethral immune profile..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Past research has already tied our gut microbiome to many diseases. However, most research to date has focused on the large intestine, as collecting stool samples is less invasive than sampling the small intestine. Recently, researchers used standard-of-care endoscopies as an opportunity to collect samples from the first section of the small intestine, the duodenum. Using quantitative sequencing, they evaluated the patients' microbial loads. They found preliminary evidence of microbes traveling from the mouth to the small intestine, as 89% of the microbial taxa found in duodenum samples were also present in saliva samples from the same patient. Within the duodenum, the researchers identified a collection of bacterial taxa that, when present, often dominated the microbial population. These ‘disruptor taxa’ appeared to replace the strict anaerobes common in the duodenum and were more prevalent in individuals with the serious GI disorder small intestinal bacterial overgrowth (SIBO)..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.