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Unraveling the genetic risk factors for Alzheimer’s disease
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"The strongest genetic risk factor for Alzheimer’s disease may impair the body’s cellular recycling system, allowing the build-up of harmful byproducts in the brain. People carrying the gene variant known as APOE4 are at an increased risk for the early development of Alzheimer’s and show high numbers of the brain plaques characteristic of the disease. But the underlying reason for this effect isn’t clear. Now, researchers have shown that APOE4 interferes with autophagy -- the body’s way of recycling unneeded or harmful cellular material – providing new insights into how and why APOE4 conveys such a strong risk for Alzheimer’s. The team looked at the relationship between APOE4 and a protein known as TFEB, considered a master regulator of autophagy-related genes. Prior studies have linked reduced TFEB expression to the presence of amyloid-beta plaques in the brain..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019
A troubling trend in Asia’s aging population
Unrestricted Use
CC BY
Rating
0.0 stars

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Asia has 365 million elderly people, and this population is expected to reach 520 million by 2030 Asian countries also had the highest rates of dementia in the 2015 World Alzheimer Report Because the risks of dementia and hypertension - which are related - increase with age, Asia is facing a troubling trend in its aging population The HOPE Asia Network conducted a much-needed review of hypertension and dementia in Asia They found that Asians had low awareness of hypertension as a major risk factor for brain damage and compared to developed countries, Asian countries had poorer hypertension management The HOPE Network emphasized the importance of controlling blood pressure variability to preserve cognitive functions by reducing vascular dementia risk and global stroke burden and suggested that Asia must focus on detecting hypertension and lowering blood pressure in midlife to protect against later-life cognitive decline in its growing elderly population Turana et al..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Applied Science
Health, Medicine and Nursing
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
09/20/2019