This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"In colorectal cancer, resistance to the chemotherapy drug 5-fluorouracil (5-FU) is a major barrier to treatment success, but the mechanism isn’t clear. To learn more, a recent study investigated 5-FU resistance in two colon cancer cell lines. Cell culture medium derived from 5-FU-resistant cells reduced 5-FU sensitivity when applied to other cells, indicating that the resistant cells secreted a resistance-inducing substance. The resistance development was accompanied by changes in the number and shape of Cajal bodies, nuclear structures that regulate RNA processing and increased phosphorylation of an important Cajal body component called coilin. Additional studies revealed that the protein UHMK1 as a kinase was responsible for resistance induction. Specifically, UHMK1 altered Cajal body assembly/disassembly and phosphorylated coilin. In turn, these effects markedly altered RNA splicing in the nucleus to affect cellular characteristics and survival and to promote protumor signaling..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 05/18/2022