This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Retinal degeneration diseases affect over 200 million people worldwide These diseases cause severe vision loss and can ultimately lead to irreversible blindness While excessive light exposure is known to damage photoreceptors and exacerbate retinal degeneration, the underlying mechanism is unclear, making it difficult to effectively treat these diseases In a recent study, researchers sought to understand the mechanisms driving light-induced photoreceptor cell death Using mouse models, they evaluated the molecular changes that occurred in retinal cells after excessive light exposure The results showed that light activated the molecules mTOR and PARP-1, initiating a unique programmed cell death mechanism termed “parthanatos” Blocking this process protected light-damaged photoreceptors, preventing cell death While additional studies are needed to determine the precise mechanisms involved and how these results translate to humans, the results suggest that targeting mTOR and PARP-1 could lead to strateg.."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 02/07/2020