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Therapeutic targeting of α- and β-adrenergic signaling for urologic diseases
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Autonomic nervous system dysfunction contributes to both benign and malignant urinary tract diseases. Thus, autonomic nervous system components that are expressed in genitourinary organs, such as α- and β-adrenoceptors, can be targeted to treat urologic disease. α-Adrenoceptors typically mediate blood vessel constriction and smooth muscle contraction, and blocking α1-adrenoceptors with antagonists relaxes the prostate and urinary tract, improving urine flow in individuals with prostate enlargement, stones, and lower urinary tract symptoms. In contrast to α-adrenoceptors, β-adrenoceptors mediate vasodilation and relaxation. Thus, β-adrenoceptor stimulants are used to treat conditions such as overactive bladder. Notably, α- and β-adrenoceptors can also be targeted to protect against acute and chronic kidney disease, and existing α- and β-adrenoceptor antagonists can be repurposed to treat genitourinary cancers..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/13/2021