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Lessons on EMT cellular dynamics from live in vivo embryo imaging
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"During epithelial-mesenchymal transition (EMT), epithelial cells lose their polarity and their cell-cell connections to become mobile, in part via transcription factor (TF) activation. EMT and its reverse process, MET, are critical for tissue development in embryos, and EMT enables wound healing during adulthood, but EMT is also how cancer cells metastasize. Live imaging of animal embryos can yield important insights into these key processes. For example, FGF and actomyosin have been found to regulate intercellular adherens junction (AJ) remodeling during EMT in fruit flies. In addition, in zebrafish embryos, the planar cell polarity (PCP) protein pk1 ensures proper EMT of neural crest cells (NCCs), and cadherin 6 ultimately regulates NCC migration..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
10/13/2021
S-1-propenylcysteine improves TNF-α-induced vascular endothelial barrier dysfunction
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Cardiovascular diseases are the number one cause of death globally. One key process central to disease development is dysfunction of the vascular endothelial barrier. Vascular endothelial cells normally maintain homeostasis by acting as a barrier, preventing the infiltration of circulating cells and proteins into tissues, but TNF-α-mediated breakdown of this barrier can cause vascular hyperpermeability, resulting in worsening disease. A new study examined a compound with the potential to protect against barrier dysfunction. S-1-propenylcysteine (S1PC) is a sulfur-containing constituent in aged garlic extract (AGE), a preparation with demonstrated anti-inflammatory and anti-atherosclerotic effects. Using TNF-α-stimulated human cell lines, researchers evaluated endothelial permeability, protein localization, and GTPase activity following treatment with AGE and S1PC. They found that AGE and S1PC reduced hyperpermeability caused by TNF-α..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
02/26/2021
The protein MICAL2 promotes gastric cancer cell migration via E-cadherin/β-catenin
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CC BY
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Gastric cancer, one of the most common cancers worldwide, is highly fatal, largely because of metastasis, a migratory process that requires rearrangement of the cellular skeleton. The protein MICAL2 is known to regulate cytoskeletal rearrangement and is highly expressed in some aggressive cancers, but whether it participates in gastric cancer metastasis is unclear. To find out, researchers recently examined MICAL2 in human gastric cancer tissues and cell lines. MICAL2 was upregulated in gastric cancer tissues compared to healthy tissues, and high MICAL2 expression was associated with reduced survival. In vitro silencing experiments on human gastric cancer cells suggested that MICAL2 encourages cell migration through the β-catenin signaling pathway. Specifically, it promotes degradation of the protein E-cadherin in a manner dependent on the cell division regulator Cdc42..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
04/14/2023