This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:
"Since the first SRC family kinase (SFK) was discovered in 1911, numerous SFKs have been identified in humans. SFKs are expressed in diverse tissues and cell types, where they regulate various biological processes. Posttranslational modification of these membrane-associated kinases can regulate their activity to affect cell signaling in different ways, but dysregulation of SFKs can promote cancer progression, invasion, and metastasis. In cancer cells, the kinases can promote epithelial-to-mesenchymal transition (EMT) to promote invasion. Specifically, they destabilize cell junctions, change cell polarity, and mediate invadopodia formation by influencing the actin cytoskeleton. SFKs also activate EMT-inducing molecules by influencing signaling pathways such as the TGF-β/SMAD, Wnt, NOTCH, and EGFR pathways. Given the roles of SFKs in cancer, SFK inhibitors have been developed as therapies for metastatic disease..."
The rest of the transcript, along with a link to the research itself, is available on the resource itself.
- Subject:
- Biology
- Life Science
- Material Type:
- Diagram/Illustration
- Reading
- Provider:
- Research Square
- Provider Set:
- Video Bytes
- Date Added:
- 10/13/2021