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Presenilin1 inhibits glioblastoma cell invasiveness by promoting Sortilin cleavage
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Alzheimer’s disease and glioblastoma are the most common and devastating diseases in neurology and neurosurgery departments. In glioblastoma, the Alzheimer’s disease-related protein Presenilin1 limits cell proliferation by inhibiting the Wnt/β-catenin pathway. However, the function of this protein and the underlying mechanism are unclear. To learn more, researchers recently examined Presenilin1’s effects on glioblastoma in vitro and in vivo. Presenilin1 repressed glioblastoma cell migration, invasion, and mesenchymal transition in vitro. Interestingly, its expression was positively correlated with that of Sortilin, a pro-invasion molecule in glioma. Presenilin1 interacted with Sortilin at the transmembrane domain and inhibited its expression via cleavage, enabling β-catenin phosphorylation and repressing invasion in glioblastoma cells. In mouse subcutaneous and intracranial transplantation models, Presenilin1 stimulation dramatically reduced glioblastoma invasion and mesenchymal transition..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/16/2022