Genetic Origins

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Subject:

Science and Technology

Institution Name:

Cold Springs Harbor

Collection:

Dolan DNA Learning Center

Grade Level:

Post-secondary

Abstract:

The goal of the Genetic Origins Program is to allow students to use their own DNA variations (polymorphisms) as a means to explore our shared genetic heritage and its implications for human health and society. Genetic Origins focuses on two types of DNA variations: an Alu insertion polymorphism on chromosome 16 (PV92) and single nucleotide polymorphisms (SNPs) in the control region of the mitochondrial (mt) chromosome. With two alleles and three genotypes, PV92 is a simple genetic system that illustrates Mendelian inheritance on a molecular level. PV92 data is readily analyzed using population statistics. The mt control region is one of the simplest regions of human DNA to sequence. With a high mutation rate, the mt control region is the "classical" system for studying human and primate evolution. The Genetic Origins site and linked Bioservers site have all the information needed for students to perform the Alu and mt DNA experiments and analyze the results - including online protocols, reagents, animations and videos explaining key concepts, and database tools.

Course Type:

Learning Module

Languages:

English

Material Type:

Activities and Labs, Simulations

Media Format:

Graphics/Photos, Text/HTML

Conditions of Use:

Custom Permissions

Copyright Holder:

Copyright Cold Springs Harbor. All rights reserved.