http://www.oercommons.org/browse/keyword/replication daily 1 2000-01-01T12:00+00:00 http://www.oercommons.org/courses/tri-nucleotide-repeat Slippage during DNA replication can lead to expanding sections of repeating nucleotides. Watch this animation to see how this problem occurs. Includes audio narration. Science and Technology 2012-10-11T22:56:55 Course Related Materials http://www.oercommons.org/courses/molecular-biology After a historical introduction to molecular biology, this course describes the basic types of DNA and RNA structure and the molecular interactions that shape them. It describes how DNA is packaged within the cellular nucleus as chromosomes. It also describes the core processes of molecular biology: replication of DNA, transcription of DNA into messenger RNA, and translation of messenger RNA into a protein. These are followed by modifications of these basic processes: regulation of gene expression, DNA mutation and repair, and DNA recombination and transposition. Upon successful completion of this course, students will be able to: discuss the experimental findings that lead to the discovery of inheritance laws; discuss the experimental findings that lead to the identification of DNA as the hereditary material; compare and contrast the structure and function of mRNA, rRNA, tRNA, and DNA; identify the characteristics of catalyzed reactions; compare and contrast enzyme and ribozyme catalyzed reactions; discuss the structure of the chromosome and the consequence of histone modifications in eukaryotes; discuss the stages of transcription, differential splicing, and RNA turnover; predict the translation product of an mRNA using the genetic code; compare and contrast transcription and translation in prokaryotes and eukaryotes; identify codon bias and variations of the standard genetic code; compare and contrast the regulation of prokaryotic and eukaryotic gene expression; predict the activation of an operon and tissue specific gene expression based on the availability of regulators; compare and contrast mutations based on their effect on the gene product; discuss DNA repair mechanisms; discuss DNA recombination, transposition, and the consequence of exon shuffling; design custom-made recombinant DNA using PCR, restriction enzymes, and site-directed mutagenesis; compare and contrast the uses of model organisms; discuss the uses of model organisms in specific molecular biology applications. (Biology 311) Science and Technology 2011-11-16T14:27:45 Course Related Materials http://www.oercommons.org/courses/genetics-2 Genetics is the branch of biology that studies the means by which traits are passed on from one generation to the next and the causes of similarities and differences between related individuals. In this course, the student will take a close look at chromosomes, DNA, and genes. The student will learn how hereditary information is transferred, how it can change, how it can lead to human disease and be tested to indicate disease, and much more. Upon successful completion of this course, students will be able to: give a brief synopsis of the history of genetics by explaining the fundamental genetic concepts covered in this course as they were discovered through time; identify the links between Mendel's discoveries (often represented by Punnett squares) with mitosis and meiosis, dominance, penetrance, and linkage; recognize the role of simple probability in genetic inheritance; apply advanced genetic concepts, including genetic mapping and transposons, to practical applications, including pedigree analysis and corn kernel color; identify the cause behind several genetic diseases currently prevalent in society (such as color blindness and hemophilia) and recognize the importance of genetic illness throughout history; compare and contrast advanced concepts of chromosomal, bacterial, human, and population genetics; recognize the similarities and differences between nuclear, chloroplast, and mitochondrial DNA; describe the fundamentals of population genetics, calculate gene frequencies in a give scenario, predict future gene frequencies over future generations, and define the role of evolution in gene frequency shift over time; recall, analyze, synthesize, and build on the foundational material to then learn the cutting-edge technological advances in genetics, including genomics, population and evolutionary genetics, and QTL mapping. (Biology 305) Science and Technology 2011-11-16T14:27:44 Course Related Materials http://www.oercommons.org/courses/cell-biology-structure-and-functions-of-the-nucleus-spring-2010 The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression. Sharp, Phillip Young, Richard Science and Technology 2011-10-22T15:48:27 Course Related Materials http://www.oercommons.org/courses/cell-division In this interactive activity adapted from the Exploratorium, explore the step-by-step process by which an animal cell divides to make more cells. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/genetics-tour-of-the-basics In this interactive activity from the University of Utah, identify different kinds of genetic traits and how they are passed on from generation to generation. View examples of simple and complex trait inheritance. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/cell-transcription-and-translation In this interactive activity adapted from the University of Nebraska, learn how and where transcription and translation occur within a cell and observe both processes in detail. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/rnai-discovered In this video segment adapted from NOVA scienceNOW, learn how RNAi, a mechanism that has evolved in cells to prevent viral infection, was discovered and how it works. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/how-do-cells-make-proteins In this interactive activity from the Exploratorium, explore the steps of protein synthesis in which the cells use genes to make proteins for critical body functions. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/rnai-explained Using scientific animations and illustrated metaphors, this interactive activity from NOVA scienceNOW explains RNAi and how it works. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/biochemistry This is a comprehensive textbook covering life functions that are ultimately interpretable in chemical terms, as chemistry is the logic of biological phenomena. Science and Technology 2008-07-14T19:33:56 Course Related Materials http://www.oercommons.org/courses/west-nile-virus-problem-space As an emerging disease in the public eye, WNV continues to generate scientific interest as well. Researchers are exploring questions about its origin, evolution, transmission by multiple vectors and host tissues, replication in multiple hosts, viremic period, viral loads, seroconversion and antibody production, detection, vaccine potential, etc. Central to these investigations are the use of molecular data including nucleic acid sequences and the use of bioinformatics. Science and Technology 2008-03-06T08:07:06 Course Related Materials http://www.oercommons.org/courses/introductory-biology-spring-2006 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution. Sive, Hazel Science and Technology 2008-01-27T10:00:48 Course Related Materials http://www.oercommons.org/courses/bioinformatics-in-the-biology-classroom This educational journal article addresses the implementation of bioinformatics in the classroom. The author explains how bioinformatics could play a key role for science students pursuing higher education, foster inquiry learning of content that has often been taught in a dry manner, provide the thread that ties classes together, improve biology teaching, enhance the learning of biotech issues and ethics, expose students to real-world science, and significantly help to reform biology teaching and improve learning. The article includes links to bioinformatics resources, information about how to get involved in bioinformatics, and a glossary of terms. Kathleen M. Gabric Science and Technology 2007-01-13T15:07:00 Course Related Materials http://www.oercommons.org/courses/microbiology-unit This College level Unit in Microbiology explores microbes on five levels, their architecture, ecology, physiology, lifecycles and pathology. Students will be given an interactive tour of the world of microbes and learn more about their impact on Humans, animals, plants and on the environment in general. They will become aware of pathogenic (harmful) and non-pathogenic (helpful) microbes and develop an understanding of how microbiologists devise methods to study microbes in order to understand their benefits and to help to minimize their deleterious effects. Kamla Reid Science and Technology 2007-01-13T15:05:00 Course Related Materials http://www.oercommons.org/courses/analysis-of-biological-networks-be-440-fall-2004 This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work will culminate in the preparation of a unique grant application in an area of biological networks. Essigmann, John Sasisekharan, Ram Science and Technology 2006-11-06T19:21:00 Course Related Materials http://www.oercommons.org/courses/7-013-introductory-biology-spring-2005 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.014 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution. Gardel, Claudette Jacks, Tyler Sive, Hazel Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/be-440-analysis-of-biological-networks-fall-2004 This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work will culminate in the preparation of a unique grant application in an area of biological networks. Essigmann, John Sasisekharan, Ram Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-012-introduction-to-biology-fall-2004 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-014-introductory-biology-spring-2005 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health and disease. Chisholm, Sallie W. Mischke, Michelle Walker, Graham Science and Technology 2006-03-20T23:43:00 Course Related Materials