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Antibiotics, Toxins, and Protein Engineering, Spring 2007

Abstract:: The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.

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The Discovery of Penicillin

Abstract:: This video segment adapted from A Science Odyssey tells the story of researcher Sir Alexander Fleming, whose luck and scientific reasoning led to the groundbreaking discovery of penicillin.

Abstract:: CK-12 Life Science Honors For Middle School covers seven units: Understanding Living Things; Cells: The Building Blocks of Life; Genetics and Evolution; Prokaryotes, Protists, Fungi, and Plants; The Animal Kingdom; The Human Body; and Ecology.

Abstract:: CK-12 Life Science For Middle School covers: Cell Biology, Genetics, Evolution, Prokaryotes, Protists, Fungi, Plants, The Animal Kingdom, The Human Body, and Ecology.

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Abstract:: This course will cover a range of diverse areas of microbiology, including virology, bacteriology, and even applied microbiology. This course will focus on the medical aspects of microbiology, as medical research has been the primary motivator in microbiology research. Upon successful completion of this course, the student will be able to: explain how organisms are classified using taxonomy, focusing on the domains Archaea, Bacteria, and Eukarya; describe the chemical building blocks and metabolic processes important to sustain microbial life; identify the major principles of microbiology and describe the relationship between microbes and other living organisms; discuss pathogenic microbes and their epidemiology; differentiate between microorganisms based on their shape, size, arrangement, staining, and culture characteristics; outline antimicrobial methods including antibiotic use; explain how the human body protects itself; list uses for microbiology in food and beverage preparation and industry. (Biology 307)