http://www.oercommons.org/browse/keyword/phenotype daily 1 2000-01-01T12:00+00:00 http://www.oercommons.org/courses/mendelian-inheritance-lab This online activity--a supplement to a hands-on lab at the Dolan DNA Learning Center's Harlem DNA Lab--asks students to analyze pigment mutations in corn and use the collected data to prove or disprove one of Gregor Mendel's conclusions (the Law of Dominance) about inheritance. David Micklos Science and Technology 2012-10-11T22:56:44 Course Related Materials http://www.oercommons.org/courses/exploring-mutant-organisms-lab In this online activity, students explore physical and behavioral mutations in two organisms--Drosophila melanogaster (the common fruit fly) and C. elegans (a microscopic worm found in soil)--to highlight the genotype-phenotype relationship and illustrate the role of mutations in human disease. David Micklos Dolan DNA Learning Center Science and Technology 2012-10-11T22:56:44 Course Related Materials http://www.oercommons.org/courses/stargenetics StarGenetics, a resource from the Massachusetts Institute of Technology, is an educational software tool that lets students mate organisms and perform various genetic analyses virtually. A free, platform-independent software product that does not require installation and allows for fly and yeast experiments, StarGenetics can be used for in-class demonstrations, virtual labs, and homework assignments. Graham C. Walker Science and Technology 2012-10-11T22:56:41 Course Related Materials http://www.oercommons.org/courses/biology-punnett-square-fun This 25-minute video lesson looks at the Punnett square diagram in the study of genetics. It covers dihybrid crosses, independent assortment, incomplete dominance, codominance and multiple alleles. [Biology playlist: Lesson 15 of 71]. Khan, Salman Science and Technology 2012-05-18T14:13:04 Course Related Materials http://www.oercommons.org/courses/biology-introduction-to-heredity This 17-minute video lesson provides an introduction to heredity and classical genetics. It looks at dominant and recessive traits as well as heterozygous and homozygous genotypes. [Biology playlist: Lesson 14 of 71]. Khan, Salman Science and Technology 2012-05-18T14:13:04 Course Related Materials http://www.oercommons.org/courses/dna-build Students reinforce their knowledge that DNA is the genetic material for all living things by modeling it using toothpicks and gumdrops that represent the four biochemicals (adenine, thiamine, guanine, and cytosine) that pair with each other in a specific pattern, making a double helix. They investigate specific DNA sequences that code for certain physical characteristics such as eye and hair color. Student teams trade DNA "strands" and de-code the genetic sequences to determine the physical characteristics (phenotype) displayed by the strands (genotype) from other groups. Students extend their knowledge to learn about DNA fingerprinting and recognizing DNA alterations that may result in genetic disorders. Denise W. Carlson Janet Yowell Malinda Schaefer Zarske Megan Schroeder Mathematics and Statistics Science and Technology 2009-11-02T09:52:37 Course Related Materials http://www.oercommons.org/courses/heredity-mix-n-match Students randomly select jelly beans (or other candy) that represent genes for several human traits such as tongue-rolling ability and eye color. Then, working in pairs (preferably of mixed gender), students randomly choose new pairs of jelly beans from those corresponding to their own genotypes. The new pairs are placed on toothpicks to represent the chromosomes of the couple's offspring. Finally, students compare genotypes and phenotypes of parents and offspring for all the "couples" in the class. In particular, they look to see if there are cases where parents and offspring share the exact same genotype and/or phenotype, and consider how the results would differ if they repeated the simulation using more than four traits. Mary R. Hebrank Mathematics and Statistics Science and Technology 2009-11-02T09:52:37 Course Related Materials http://www.oercommons.org/courses/convergence-marsupials-and-placentals This graphic illustrates some of the marsupial mammals in Australia and placental mammals in North America. Even though they are not closely related, these mammals look alike because they have adapted to similar ecological roles. From The Human Evolution Coloring Book by by Adrienne Zihlman. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/tetrapod-limbs This illustration from Evolution by Monroe W. Strickberger shows the remarkable similarities between the bones in the forelimbs of various tetrapods, all of whose limbs serve very different functions. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/animal-body-plans-homeobox-genes The homeobox genes that define the basic body plan of mice and fruit flies are illustrated in this graphic from The Human Evolution Coloring Book by Adrienne Zihlman. The accompanying article describes how these genes act as molecular architects in all animal species. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/chromosome-viewer This interactive feature provides a microscopic view of the 24 Human chromosomes. Each chromosome is labeled with the names of some of the genetic conditions and traits associated with particular regions on that chromosome. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/how-genetic-disorders-are-inherited Learn how genetic disorders are passed from parents to children as explained in this excerpt from Blazing a Genetic Trail, from the Howard Hughes Medical Institute. Science and Technology 2009-08-13T00:25:40 Course Related Materials http://www.oercommons.org/courses/the-making-of-individual-differences How do we become individuals? This unit looks at how genes and the environment interact making each of us unique. Looking at the period between conception and birth you will examine the issues of nature or nurture to see which has the greatest impact. The Open University Science and Technology 2008-05-30T09:25:33 Course Related Materials http://www.oercommons.org/courses/7-03-genetics-fall-2004 The principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes and genomes. Biological variation resulting from recombination, mutation, and selection. Population genetics. Use of genetic methods to analyze protein function, gene regulation and inherited disease. Fink, Gerald Kaiser, Chris Mischke, Michelle Samson, Leona Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-90j-computational-functional-genomics-spring-2005 Study and discussion of computational approaches and algorithms for contemporary problems in functional genomics. Topics include DNA chip design, experimental data normalization, expression data representation standards, proteomics, gene clustering, self-organizing maps, Boolean networks, statistical graph models, Bayesian network models, continuous dynamic models, statistical metrics for model validation, model elaboration, experiment planning, and the computational complexity of functional genomics problems. Gifford, David Jaakkola, Tommi Sakari Science and Technology 2006-03-20T23:43:00 Course Related Materials