http://www.oercommons.org/browse/keyword/mrna daily 1 2000-01-01T12:00+00:00 http://www.oercommons.org/courses/antibiotics-toxins-and-protein-engineering-spring-2007 The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching. Sassanfar, Mandana Science and Technology 2008-01-27T10:00:48 Course Related Materials http://www.oercommons.org/courses/biochemistry This is a comprehensive textbook covering life functions that are ultimately interpretable in chemical terms, as chemistry is the logic of biological phenomena. Science and Technology 2008-07-14T19:33:56 Course Related Materials http://www.oercommons.org/courses/bioinformatics-homework-assignment-accessing-and-analyzing-nucleic-acid-sequence-data-from-ncbis-database This undergraduate activity introduces students to bioinformatics. During the guided activity students will access the National Center for Biotechnology Information's (NCBI) genetic sequence database to obtain and study DNA sequence entries relating to the chicken ovalbumin mRNA and genomic sequences. Sandra Sharp Science and Technology 2007-01-13T15:04:00 Course Related Materials http://www.oercommons.org/courses/5-08j-biological-chemistry-ii-spring-2004 More advanced treatment of biochemical mechanisms that underlie biological processes. Emphasis on experimental methods used to unravel these processes, and how these processes fit into the cellular context and coordinate regulation of these processes. Topics include macromolecular machines for energy and force transduction, regulation of biosynthetic and degradative pathways, and structure and function of nucleic acids. Stubbe, JoAnne Science and Technology 2006-03-20T23:44:00 Course Related Materials http://www.oercommons.org/courses/cell-biology-structure-and-functions-of-the-nucleus-spring-2010 The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression. Sharp, Phillip Young, Richard Science and Technology 2011-10-22T15:48:27 Course Related Materials http://www.oercommons.org/courses/dna-the-human-body-recipe As a class, students work through an example showing how DNA provides the "recipe" for making our body proteins. They see how the pattern of nucleotide bases (adenine, thymine, guanine, cytosine) forms the double helix ladder shape of DNA, and serves as the code for the steps required to make genes. They also learn some ways that engineers and scientists are applying their understanding of DNA in our world. Denise W. Carlson Frank Burkholder Jessica Todd Malinda Schaefer Zarske Mathematics and Statistics Science and Technology 2009-11-02T09:52:37 Course Related Materials http://www.oercommons.org/courses/dogma-of-molecular-biology Dogma of Molecular Biology Ewa Wosik Science and Technology 2007-08-20T05:11:00 Course Related Materials http://www.oercommons.org/courses/7-16-experimental-molecular-biology-biotechnology-ii-spring-2005 Laboratory uses yeast as an experimental system to study fundamental problems in understanding cell cycle and chromosome segregation. Experimental work combines genetic approaches with the tools of molecular and cell biology to identify and characterize novel genes that act on these processes. Instruction and practice in written and oral communication provided. Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-03-genetics-fall-2004 The principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes and genomes. Biological variation resulting from recombination, mutation, and selection. Population genetics. Use of genetic methods to analyze protein function, gene regulation and inherited disease. Fink, Gerald Kaiser, Chris Mischke, Michelle Samson, Leona Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-012-introduction-to-biology-fall-2004 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-014-introductory-biology-spring-2005 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health and disease. Chisholm, Sallie W. Mischke, Michelle Walker, Graham Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/7-013-introductory-biology-spring-2005 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.014 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution. Gardel, Claudette Jacks, Tyler Sive, Hazel Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/introductory-biology-spring-2006 The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution. Sive, Hazel Science and Technology 2008-01-27T10:00:48 Course Related Materials http://www.oercommons.org/courses/microarray-experiments This module is designed to familiarize the student with the basic principals behind microarray experiments and microarray data analysis. Susan Cates Science and Technology 2007-10-30T11:44:00 Course Related Materials http://www.oercommons.org/courses/7-344-rna-interference-a-new-tool-for-genetic-analysis-and-therapeutics-fall-2004 Seminar covering topics of current interest in biology. Includes reading and analysis of research papers and student presentations. Contact Biology Education Office for topics. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has already changed the way biomedical research is done and that may even prove useful for genetic interventions in a clinical context. In this course, students learn how RNAi was discovered, how it works, and what its physiological relevance might be. How RNAi can be harnessed to modulate gene expression and perform genetic screens, both in cells and in various organisms is also covered. Finally, this course examines the first attempts to use RNAi for the treatment of models of human diseases in experimental animals. Kissler, Stephan Ventura, Andrea Science and Technology 2006-03-20T23:43:00 Course Related Materials http://www.oercommons.org/courses/reading-dna In this activity, learners use edible models of the DNA molecule to transcribe an mRNA sequence, and then translate it into a protein. This activity requires learners to have already constructed edible DNA models from the activity "Have Your DNA and Eat It Too" (see related resource). April Mitchell Harmony Starr Louisa Stark Molly Malone Science and Technology 2012-11-30T18:31:44 Course Related Materials http://www.oercommons.org/courses/p53 A 3D animation showing the molecule p53 binds to DNA and initiates the transcription of mRNA. Science and Technology 2012-10-11T22:56:53 Course Related Materials