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The role ceramide plays in nerve cells is related to its source
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This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"In nerve cells, the waxy molecule ceramide plays roles in both cellular differentiation and death, but a new study shows those roles could vary based on how ceramide is formed. Ceramide is generated via 3 pathways: newly from palmitoyl-CoA and serine, from the breakdown of sphingomyelin, and through the endosomal salvage pathway. Experiments showed that blocking ceramide synthesis did not alter ceramide levels in PC12 cells, which require nerve growth factor (NGF) to survive and differentiate, but blocking synthesis did decrease ceramide levels in TrkA cells, which differentiate spontaneously. Blocking sphingomyelin breakdown, however, inhibited differentiation and reduced ceramide in both cell lines. Without NGF, PC12 cells begin to atrophy and die, and preventing sphingomyelin breakdown did not protect them, but it did suppress rising ceramide levels to some degree versus controls..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Subject:
Biology
Life Science
Material Type:
Diagram/Illustration
Reading
Provider:
Research Square
Provider Set:
Video Bytes
Date Added:
05/17/2022