Analyzes computational needs of clinical medicine reviews systems and approaches that have been used to support those needs, and the relationship between clinical data and gene and protein measurements. Topics: the nature of clinical data; architecture and design of healthcare information systems; privacy and security issues; medical expertsystems; introduction to bioinformatics. Case studies and guest lectures describe contemporary systems and research projects. Term project using large clinical and genomic data sets integrates classroom topics.

This course will cover fundamentals of digital communications and networking. We will study the basics of information theory, sampling and quantization, coding, modulation, signal detection and system performance in the presence of noise. The study of data networking will include multiple access, reliable packet transmission, routing and protocols of the internet. The concepts taught in class will be discussed in the context of aerospace communication systems: aircraft communications, satellite communications, and deep space communications.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"How does a person experiencing anesthesia lose consciousness? Despite billions of surgeries, scientists still don’t fully understand what happens in the brain when a patient goes under. New research in the journal Anesthesiology, however, provides a few more clues. Working in a group of patients with epilepsy, scientists used a new information measure to evaluate electrocorticography data -- and found that with anesthesia, there is a reduction in information integration and network connectivity. The team recorded electrocorticograms, or intracranial E-E-Gs, from nine patients who were anesthetized predominantly with propofol and underwent surgical treatment for epilepsy in China. To assess information integration, the team used a measure called [genuine permutation cross mutual information], or G-P-C-M-I. In an earlier study, they found the measure performed better than others using scalp EEG recordings..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Word Count: 280219

ISBN: 978-0-9997970-1-3

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

Long before the internet people thought about sending information along wires using static electricity. Created by Brit Cruise.

How can we communicate in the presence of noise? Created by Brit Cruise.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Adoptive cell therapy is a powerful anticancer strategy in which patients are administered extra immune cells. Often, the cells are engineered to express chimeric antigen receptors (CARs) that recognize specific cancer cell proteins (antigens), enabling cancer targeting. The strength of the anticancer effect depends on structures within the CARs called costimulatory domains. One such domain, 4-1BB, activates the NFκB signaling pathway, but the relationship between the amount of antigen present and the strength of the elicited response isn’t well described. To help, researchers recently developed a mathematical model of NFκB signaling induced by a 4-1BB-containing CAR. Simulations revealed that the degree of NFκB pathway activation differed in response to different antigen concentrations, but the timing was consistent. The model performed well even when the input parameters were changed, suggesting its reliability under different conditions..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

Finally we arrive at our quantitative measure of entropy. Created by Brit Cruise.

Word Count: 31669

(Note: This resource's metadata has been created automatically by reformatting and/or combining the information that the author initially provided as part of a bulk import process.)

This course gives a mathematical introduction to neural coding and dynamics. Topics include convolution, correlation, linear systems, game theory, signal detection theory, probability theory, information theory, and reinforcement learning. Applications to neural coding, focusing on the visual system are covered, as well as Hodgkin-Huxley and other related models of neural excitability, stochastic models of ion channels, cable theory, and models of synaptic transmission.
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Rosetta Stone, 196 B.C.E., granite, 114.4 cm x 72.3 x 27.9 cm or 45 x 28.5 x 11 inches, Ptolemaic Period (British Museum, London). Speakers: Dr. Beth Harris and Dr. Steven Zucker. Created by Beth Harris and Steven Zucker.

This resource is a video abstract of a research paper created by Research Square on behalf of its authors. It provides a synopsis that's easy to understand, and can be used to introduce the topics it covers to students, researchers, and the general public. The video's transcript is also provided in full, with a portion provided below for preview:

"Dysregulation of the IL-6-induced JAK/STAT cascade is associated with severe inflammatory and proliferative diseases. The cascade is normally tightly controlled by proteins such as the feedback inhibitor SOCS3 and the tyrosine phosphatase SHP2. SOCS3 increases the stability of late IL-6-induced STAT3 activation across cells with different STAT3 levels and reduces the signal magnitude. but whether SHP2 similarly affects robustness and information transfer remains unclear. Researchers recently used multiplexed single-cell analyses and information theory approaches to clarify SHP2’s roles. They found that SHP2 improved the robustness of STAT3 activation under basal conditions (in the absence of the cytokine IL-6) and during early IL-6 signalling levelling the degree of activation across cells with heterogeneous expression levels of STAT3. However, it did not affect the robustness of late IL-6-induced STAT3 activation..."

The rest of the transcript, along with a link to the research itself, is available on the resource itself.

This class teaches the fundamentals of signals and information theory with emphasis on modeling audio/visual messages and physiologically derived signals, and the human source or recipient. Topics include linear systems, difference equations, Z-transforms, sampling and sampling rate conversion, convolution, filtering, modulation, Fourier analysis, entropy, noise, and Shannon's fundamental theorems. Additional topics may include data compression, filter design, and feature detection. The undergraduate subject MAS.160 meets with the two half-semester graduate subjects MAS.510 and MAS.511, but assignments differ.